Transmitter Biochemistry of Human Brain Tissue: Proceedings by Earl Usdin, Peter Riederer

By Earl Usdin, Peter Riederer

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Extra resources for Transmitter Biochemistry of Human Brain Tissue: Proceedings of the Symposium held at the 12th CINP Congress, Göteborg, Sweden June, 1980

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1980) the hypothalamic noradrenaline- (NA) level fluctuated significantly during the day (Figure 1). The norrnetanephrine- (NM) and the 3-methoxy-4hydroxy-phenylenglycol- (MHPG) level showed similar variations. There is a peak in the night in hypothalamus of NA and a nadir between 9 and 12 in the day. Of interest is that the circadian rhythm of NA alm:::>st ntirror the circadian rhythm of cortisol (Sachar, 1977). m. The investigation by Carlsson et al. (1980) was made on post-m:::>rtem human brain material where the hour of death was recorded.

The major site of methylation is however the 4-hydroxyl group rather than the 3-hydroxyl group. This difference we attribute to the ionisation of the 4-hydroxyl group that results from the juxta position of the fluorine atom in 5-fluoro dopa (Firnau, Pantel and Garnett, 19Bo). 5-Fluoro dopamine binds to dopamine receptors derived from a homogenate of rat caudate nucleus and competes with 3H-spiroperidol. The'C50 for this competition is 63 x 10-6M. 5-Fluoro dopamine also stimulates the release of cyclic-AMP by adenylate cyclase.

G, 847-853. , Kothbauer, P. (1978). Changes of some putative neurotransmitters in human cerebral infarction. ,31-44. M. (1978). Positive identification of kynurenine in rat and hrnren brain. Trans. ~, 123. V. (1977). Concentrations of energy metabolites and cyclic nucleotides during and after bilateral ischemia in the gerbil cerebral cortex. ~,53-59. , Busto, H. (1976). The role of monoamines and cyclic AMP in ischemic brain edema. In Dynamics in brain edema, (eds. Feindell), pp 203-214. Springer, Berlin-Heidelberg-New York.

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