The Heffter Review of Psychedelic Research by David E. Nichols (ed.)

By David E. Nichols (ed.)

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Finally, the reticular formation, which is activated by input from all sensory modalities, gives rise to serotonergic projections to the components of the CST loops, namely the frontal cerebral cortex, cingulate cortex, hippocampus, striatum, nucleus accumbens, thalamus, and amygdala. Excessive activation of the postsynaptic elements of these serotonergic projection sites should also result in a reduction of the thalamic gating mechanism and, consequently, in a sensory overload of frontal cortex resulting in psychosis.

In Pletscher A, Ladewig D (eds), 50 Years of LSD: State of the Art and Perspectives of Hallucinogens. Symposium of the Swiss Academie of Medical Sciences, October 21-22, 1993, Lugano-Agno, Switzerland. London, Parthenon Publishing, pp. 67-86. Vollenweider FX, Gamma A, Baer T, et al. (1996) Ketanserin, a 5-HT2 antagonist, but not haloperidol, effectively blocks psilocybininduced model psychosis in healthy volunteers. [Abstract] WPA-Abstractbook: 116 Vollenweider FX, Antonini A, Leenders KL, Mathys K.

Neuropsychopharm 16:357-372 Vollenweider FX, Liechti M, Gamma A, Hell D, Geyer M. (1997e) Effects of MDMA ("ecstasy") on sensorimotor gating, attention, and mood in healthy volunteers. [Abstract] The State of the Art in Psychiaty/Abstracts 1997: 28 Vollenweider FX, Liechti M, Gamma A, Huber T. (1997f): Psychological and cardiovascular effects and short-term sequale of MDMA ("Ecstasy") on MDMA-naive healthy volunteers. [submitted] Neuropsychopharm. Vollenweider FX, Vontobel P, Hell D, Leenders KL (1997g) Evidence for 5-HT2 mediated increase of basal ganglia dopamine release in human model psychosis - a PET study with [11C]raclopride [Abstract] The State of the Art in Psychiaty/Abstracts 1997: 39.

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