The Biology of Germinal Centers in Lymphoid Tissue by G. Jeanette Thorbecke, Vincent K. Tsiagbe

By G. Jeanette Thorbecke, Vincent K. Tsiagbe

This publication meets the call for of a up to date surge of curiosity in germinal facilities, the foci of antigen-induced, quickly proliferating B lymphocytes, representing websites in mammalian lymphoid tissue the place reminiscence B cells are generated. a variety of features of the iteration of germinal facilities, the somatic hypermutation technique and the mobile interactions inquisitive about the choice strategy are mentioned intimately. A bankruptcy on germinal center-derived lymphomas completes the treatment.

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J. Switch to IgG3 + IgBJ. ; LN sizeJ. J. ; FDdJ,J, J,J, ,I. J,; IgEJ,J, Normal** 578 STAT4-I - IL-12-induced Th1 RespJ,J, Th2 ii;NKJ. ; Memory B cells ,I. J,J. J,J, SHP-1+/ B cells Spont. 2a,b,c on following page. 2a,b,c footnotes * Tg designates overexpression of transgene; -1- designates knockout gene. Ag = antigen; Ab = antibody; CFA = Complete Freund's Adjuvants; LN = Lymph nodes; Spl = spleen; Resp. = response; Prim. = primary; Sec. = secondary; TD = Thymus dependent; TI thymus independent.

GC Function and Structure in Normal and Genetically Engineered Mice 29 In the absence of B cells, FDCs have smaller and fewer processes and are considered precursors of FDCs. 235 In SCID mice, few FDCs are found and their reconstitution by cell transfers showed that the combination of Band T cells was more effective than B cells alone. 236 This finding, as well as the observed paucity of FDCs in follicles from CD40L deficient individuals,128 suggest that T-B cell interaction is stimulating for FDC development.

It seems possible that being retained in lymph node follicles through antigen fixed on FDCs prolongs the survival of these memory cells. Functions of GCs and the Cellular Interactions that Contribute to These Functions The functions of GCs differ somewhat in different species. In most mammals, GCs are sites where the generation of memory B cells occurs, accompanied by Ig gene V region somatic hypermutation. 199 However, GCs are also used as sites for primary B cell Ig gene diversification by some species, particularly the rabbit.

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