Stereotactic Body Radiation Therapy by Brian D. Kavanagh MD MPH, Robert D. Timmerman MD

By Brian D. Kavanagh MD MPH, Robert D. Timmerman MD

This article offers oncology execs with a realistic knowing of the elemental technological know-how, technical points, and scientific symptoms of stereotactic physique radiation treatment, together with radiosurgery, radiotherapy, and radioablation. assurance comprises discussions of correct classical and molecular radiobiological ideas, severe reviews of presently used suggestions, and heritage medical oncology details plus summaries of pronounced results for sufferers taken care of within the lung, liver, and backbone.

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Interferon (19, 20), and tyrosine kinase inhibitors (21)]. We await the findings of current studies on promising new agents (22). A few drugs that have been very successful in the clinic appear to work by blocking cytokines and therefore predisposing cells to apoptosis. The most important of these is trastuzumab (Herceptin). For women with breast cancer that expresses her-2, a growth factor receptor in the epidermal growth factor (EGF) family, suppression of the receptor by this blocking antibody can precipitate apoptosis.

22. Douglas BG, Fowler JF. The effect of multiple doses of x-rays on skin reactions in the mouse and a basic interpretation. Radiat Res 1976;6:401-426. 23. Hall EJ. The oxygen effect and reoxygenation. In: Hall EJ, ed. Radiobiology for the Radiobiologist, 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2000. 24. Tomé WA, Fowler JF. On cold spots in tumor subvolumes. Med Phys 2002;29:1590-1598. 25. Niemierko A, Goitein M. Implementation of a model for estimating tumor control probability for an inhomogeneously irradiated tumor.

A platelet clot is seen attached to the exposed arterial basement membrane. The endothelial cells are atypical and hypertrophic. The picture is one of proliferation rather than cell depopulation. The proliferating inflammatory cells were therefore recruited to the irradiated volume by cell signaling phenomena in the tissues that were damaged by the irradiation. The entire process is governed by a cascade of cytokines. Interleukin-1 The radiation-induced expression of IL-1 has been demonstrated in a number of studies (2).

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