Somitogenesis Part 1 by Charles P. Ordahl (Eds.)

By Charles P. Ordahl (Eds.)

The chapters contained during this two-volume set offer a wide standpoint at the novel options and conceptual paradigms that force the present resurgence of curiosity in somitogenesis - the method during which somites shape and tricky differentiated tissues and buildings. simply because somites are a ubiquitous characteristic of vertebrate embryos, they are often studied in a number of experimental animal versions together with these amenable to genetic (zebrafish, mammalian), molecular/genetic (mammalian, avian) in addition to these already good validated for classical experimental embryological and cellphone organic experiences (amphibians, avian). the wide range of experimental ways to somitogenesis which are awarded in those volumes will depart the reader with a wide viewpoint on how present study in somitogenesis helps to resolve primary questions in vertebrate improvement and morphogenesis. Key gains: * Novel transcriptional mechanisms that keep an eye on repetitive development formation * vast scale genetic displays for mutations affecting somitogenesis * Molecular/genetic keep an eye on of development and tissue formation in the course of somitogenesis * Transplantation of mouse embryo somites * Classical embryological techniques and ideas * Evolutionary views on somitogenesis

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Somitogenesis Part 1

The chapters contained during this two-volume set supply a wide viewpoint at the novel concepts and conceptual paradigms that force the present resurgence of curiosity in somitogenesis - the method during which somites shape and intricate differentiated tissues and buildings. simply because somites are a ubiquitous characteristic of vertebrate embryos, they are often studied in various experimental animal types together with these amenable to genetic (zebrafish, mammalian), molecular/genetic (mammalian, avian) in addition to these already good confirmed for classical experimental embryological and mobile organic stories (amphibians, avian).

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1994; Tam and Trainor, 1994). Clearly, however, the link between these two distant stages is missing, and the most convincing of these experiments have been done in the chick, with little being known for mammals. Furthermore, there has been no attempt, so far, to obtain a complete description of the properties for all possible ancestral cells of the progenitors to the muscle system. This is because classic methods are not amenable to long-term studies (Gardner and Lawrence, 1985; Beddington and Lawson, 1990), nor do they permit one to follow groups of cells at all stages of development.

Exp. Morphol. 92, 269-285. Tam, P. P. L. (1988). The allocation of cells in the presomitic mesoderm during somite segmentation in the mouse embryo. Development 103,379-390. Tam, P. P. , and Beddington, R. S. P. (1986). The metameric organisation ofthe presomitic mesoderm and somite specification in the mouse embryo. f n “Somites in Developing Embryos” (R. Bellairs, D. A. Ede, and J. W. ). NATO AS1 Series, Vol. 118, pp. 17-36. Plenum, New York. Tam, I? I? L.. and Beddington, R. P. (1987). The formation of mesodermal tissues in the mouse embryo during gastrulation and early organogenesis.

And Turner, D. L. (1996). The Notch pathway: Democracy and aristocracy in the selection of cell fate. C u m B i d . 6,594-601. Krull. C. , Gale, N. , Yancopoulos, G. , Fraser, S. , and Bronner-Fraser, M. (1997). Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration. Curr. B i d . 7,571-580. Lardelli, M. (1995). Complementary and coinbinatorial patterns of Notch gene family expression during early mouse development. Mech. Dev. 53,357-368.

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