Presbyopia Research: From Molecular Biology to Visual by Ana B. Chepelinsky, Eric F. Wawrousek, Robert A. Dubin,

By Ana B. Chepelinsky, Eric F. Wawrousek, Robert A. Dubin, Cynthia J. Jaworski (auth.), Gérard Obrecht, Lawrence W. Stark (eds.)

Seeing is existence. Seeing is transfonning luminous col­ we want to expand our instructional and theoretical ored stimulations and shapes into amental represen­ wisdom and in addition to accomplish and alternate our tation, based in area and in time. yet seeing is technical adventure to arrange additionally starting onto the realm that surrounds us: it really is corrective capability for the long run. hence a method for speaking and studying. a number of questions have not begun to be spoke back, Jean-Jacques Rousseau, a thinker worthy corresponding to: quoting in the course of the bicentennial of the French Revo­ lution of which he was once an instigator, acknowledged, "of all • Will it in the future be attainable to defer or cease the the senses, imaginative and prescient is that wh ich will be the least getting older of the accommodative equipment? effortlessly separated from judgments of the brain. " • Is additional development of the present corrective Sight is more and more known as on in our smooth capacity attainable, even if spectacles or touch global. adulthood is affected at approximately 40-45 years by way of lenses? the on set of presbyopia. Atthat age, which calls for • How are behavioral and mental presbyope all our highbrow and actual skill, our sight typologies to be built-in during examination­ might be irreproachable. Our potency must never be ination, prescription, and becoming with corrective diminished.

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Counis, M. , 1987, Characterization of acidic and basic fibroblast growth factors in brain, retina and vitreous chick embryo, Biochem. Biophys. Res. Commun. 146:478-486. , 1989, Evidence for a relationship between longevity of mammalian species and a lens growth parameter, Gerontology (in press). , 1986, Effects of Heparin on the stimulation of nonvascular cells by human acidic and basic FGF, Biochem. Biophys. Res. Commun. 137: 1205-1213. , 1987, Endothelial cell derived basic fibroblast growth factor: Synthesis and deposition into subendothelial extracellular matrix, Proc.

1985, A retina derived growth factor regulates epithelial cell proliferation in cultured lens, Differentiation 28:286-290. , 1988, "Nucleotide sequence of acidic fibroblast growth factor CDNA, Nucl. Ac. Res. " Huang, S. , and Huang, Y. , 1986, Association ofbovine brainderived growth factor receptor with protein tyrosine kinase activity, Biochemistry 261:9568-9571. Jeanny, J. , 1987, Specific fixation of bovine brain and retinal acidic and basic fibroblast growth factor to mouse embryonic eye basement membranes, Exp.

Freeze-fracture experiments make it possible to visualize the terminal segment of IF apparently exposed at the hydrophobie fracture face of the plasma membrane. , 1982). , 1982). The membrane association of vimentin occurs even when the translation is completed. New interesting experimental data concem the interaction of vimentin with ankyrin. , 1985; Georgatos and Marchesi, 1985). The ankyrin-vimentin association in a noncooperative manner prevents deploymerization of IF. This interaction likely blocks the NH 2 terminal of vimentin, which is known to be implicated in the polymerization process of IF.

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