PET-CT in Radiotherapy Treatment Planning by Arnold C. Paulino MD

By Arnold C. Paulino MD

This is a thrilling new consultant to using PET-CT imaging in radiotherapy. you will get functional, necessary info for using this novel imaging technique-from varied equipment for contouring organic goal volumes in a variety of anatomic areas to how assorted specialists use this imaging in designated therapy. This thorough textual content is helping you're making concise, exact therapy offerings according to present proof and professional authority. the result's an important device for everybody at the radiotherapy therapy staff within the period of image-guided radiotherapy.Helps familiarize you with the fundamentals of puppy imaging in nuclear medicine.Covers using PET-CT with radiotherapy therapy making plans, supplying sensible counsel in how various specialists use this really new technology.Highlights distinction utilizing full-color pictures, essentially indicating goal volumes and varied radiation dosages.Outlines the benefits and downsides of other recommendations in contouring PET-CT objective volumes for radiotherapy.Features case illustrations in utilizing PET-CT in radiotherapy remedy making plans for various tumor websites.

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There is no corresponding abnormal uptake seen. Often, this intracellular trapping is due to lack of specific enzymes, most notably glucose-6-phosphatase, which can lead to dephosphorylation and subsequent diffusion of tracer outside the cell. Normal cells possess abundant phosphatases, enabling normal metabolism of FDG and excretion of breakdown products out of the cell. In addition, most malignant cells do not possess the enzyme machinery to complete the Krebs' cycle, leading to intracellular accumulation of FDG.

45. , et al: Does registration of PET and planning CT images decrease interobserver and intraobserver variation in delineating tumor volumes for non-small-cell lung cancer?. Int J Radiat Oncol Biol Phys 2005; 62:70-75. 46. , et al: Reduction of observer variation using matched CT-PET for lung cancer delineation: a three-dimensional analysis. Int J Radiat Oncol Biol Phys 2006; 64:435-448. 47. , et al: Impact of combined 18F-FDG PET/CT in head and neck tumours. Br J Cancer 2005; 92:1046-1050. 48.

Et al: A novel approach to overcome hypoxic tumor resistance: Cu-ATSM-guided intensity-modulated radiation therapy. Int J Radiat Oncol Biol Phys 2001; 49:1171-1182. 67. , et al: Combined uptake of (18F) FDG and (18F) FMISO correlates with radiation therapy outcome in head-and-neck cancer patients. Radiother Oncol 2006; 80:151-156. 68. 02. J Clin Oncol 2006; 24:2098-2104. 69. , et al: Respiratory gating for 3-dimensional PET of the thorax: feasibility and initial results. J Nucl Med 2004; 45:214-219.

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