Organizing Principles of Neural Development by Julian Smith, Nicole M. Le Douarin (auth.), S. C. Sharma

By Julian Smith, Nicole M. Le Douarin (auth.), S. C. Sharma (eds.)

This quantity comprises summaries of many of the invited shows on the NATO complex learn Institute "Organizing ideas of Neural Development", held in Povoa de Varzim, Portugal, from June 1-12, 1982. The assembly used to be meant to compile a decide upon workforce of investigators to provide their perspectives on difficulties within the box and to foster huge discussions in smaller teams. It used to be was hoping that such communications might pique curiousity and creativity one of the scholars and therefore assist in formulating extra hypotheses concerning the kind of interactions which would underlie neural improvement. regardless of the big variety of fabric coated at this institute, a standard topic appeared to emerge: in any respect phases in their increase­ psychological historical past, the cells of the anxious process engage with formerly generated cells (both neurons and non-neurons) in addition to with different elements of the developmental milieu. The pre­ sentations at this assembly helped in comprehending how a comparatively "simple" sequence of sequential occasions could give you the invaluable info had to generate the range, attribute of the grownup frightened method, with out hypothesizing at the life of particular genes appearing to regulate every one step.

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GFA-positive and GFA-negative (Levitt. Cooper and Rakic. 1981). A diagram provided in Figure 4 summarizes. in a somewhat simplified manner. both the previous and present theories of the origin of neuronal and glial cell lines in the primate telencephalic wall. The main point relevant to this presentation is that from the earliest stages. both glial and DEVELOPMENT OF PRIMATE CEREBRAL CORTEX 29 neural cells and their mutual interactions have to be taken into account in considering cortical development (Rakic, 1981b).

The subventricular zone lies some distance below the reconstructed area, whereas the cortex is more than 1000 ~m above it. The lower portion of the diagram contains uniform, paralled fibers of the optic radiation (OR) and the remainder is occupied by more variable and irregularly disposed fiber systems; the border between the two systems is easily recognized. Except at the lower portion of the figure, most of these fibers are deleted from the diagram to expose the radial fibers (striped vertical shafts RFl-6) and their relationships to the migrating cells A, B and C and to other vertical processes.

33 DEVELOPMENT OF PRIMATE CEREBRAL CORTEX J- 1- - - - - -1 - - _ . - 2- 1--- - - - -1 r· ... , , ~--... c B A Figure 6. Diagram showing a possible mechanism for the displacement of migratory cells along the surface of radial glial fibers (vertical shafts A-C). To traverse the distance between levels 1 and 2, new plasma membrane may be inserted along the interface of the two cells (dashed line in A), while the cell nucleus becomes translocated within the cytoplasm of the leading process (B). As the leading tip grows to reach level 3, additional new membrane is inserted (dotted line in C) along the interface with the glial surface and the nucleus moves to a higher position between levelland 2, resulting in an overall displacement of the cell body.

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