Molecular Vaccines: From Prophylaxis to Therapy - Volume 2 by Hiroyuki Sasamura MD, PhD, Tasuhiko Azegami MD, PhD, Hiroshi

By Hiroyuki Sasamura MD, PhD, Tasuhiko Azegami MD, PhD, Hiroshi Itoh MD, PhD (auth.), Matthias Giese (eds.)

This identify discusses all elements of non-infectious and non-cancer– so known as NINC – vaccines. high blood pressure, diabetes and hypersensitive reaction vaccine improvement are often called good because the use of adjuvants and nanotechnology in vaccine improvement. the way in which of novel vaccines from bench to preclinical to scientific reports and release to the industry less than EMEA (European medicinal drugs employer) and FDA (Food and Drug management) instructions are defined in-depth. The booklet is for that reason of curiosity for researchers and clinicians engaged in vaccine improvement and molecular vaccine application.

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Effect of immunization with homologous LDL and oxidized LDL on early atherosclerosis in hypercholesterolemic rabbits. Arterioscler. Thromb. Vasc. Biol. 16, 1074–1079 (1996) 33. : Vaccination for atherosclerosis. Clin. Rev. Allergy Immunol. 38, 135–140 (2010) 34. : Vaccination strategies in atherosclerosis. Thromb. Haemost. 106, 796–803 (2011) 35. : Vaccines modulating lipoprotein autoimmunity as a possible future therapy for cardiovascular disease. J. Intern. Med. 266, 221–231 (2009) 36. : Inhibition of atherosclerosis in apoE-null mice by immunization with apoB-100 peptide sequences.

That vaccines based on apoB peptide antigens may be an important candidate for the development of vaccines for atherosclerosis [35]. Fredrikson et al. examined the effects of immunization with apoB100 peptide sequences on the development of atherosclerotic lesions in hypercholesterolemic mice and found a 60 % reduction in atherosclerosis [36]. Interestingly, it was later shown that an antiatherogenic effect could be found in the absence of an increase in peptide-specific IgG, suggesting the contribution of cellular immune responses in the atheroprotective effect [37].

Phentermine belongs to a class of drugs that stimulate the central nervous system and conveys a response of “fight or flight” which blocks the feeding drive and induces anorexia. The most common side effects associated with phentermine include insomnia, irritability, and increase in blood pressure [12]. Sibutramine and rimonabant are another two appetite suppressant drugs that were recently withdrawn from the market due to safety concerns, after suspension being recommended due to cardiovascular and psychiatric side effects, respectively.

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