Molecular Imaging: An Essential Tool in Preclinical by B. Tavitian (auth.), A. A. Bogdanov Jr., K. Licha (eds.)

By B. Tavitian (auth.), A. A. Bogdanov Jr., K. Licha (eds.)

The non-stop development within the realizing of molecular procedures of disorder formation and development attributes an expanding significance to biomedical molecular imaging tools. the aim of this workshop used to be to debate and review a number of purposes and rising applied sciences within the quarter of diagnostic imaging together with its basic services in preclinical examine, the possibilities for remedy, and the choices concerning healing strategies. The ebook presents the reader with state of the art info at the various elements of diagnostic imaging, illuminating new advancements in molecular biology, imaging brokers and molecular probe layout, and healing techniques.

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Methods 29:110±122 Luker G, Sharma V, Piwnica-Worms D (2003 c) Noninvasive imaging of protein-protein interactions in living animals. In Conn PM (ed) Handbook of proteomic methods. , Totowa, NJ, pp 283±298 Ogawa H, Ishiguro S, Gaubatz S, Livingston D, Nakatani Y (2002) A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science 296:1132±1136 Ostermeier M, Nixon A, Shim J, Benkovic S (1999) Combinatorial protein engineering by incremental truncation. Proc Natl Acad Sci USA 96: 3562±3567 Ozawa T, Kaihara A, Sato M, Tachihara K, Umezawa Y (2001) Split luciferase as an optical probe for detecting protein-protein interactions in mammalian cells based on protein splicing.

2002). Furthermore, bioluminescence imaging of animals using charged couple device (CCD) cameras such as the IVIS (Xenogen, Alameda, CA) enabled us to quantify relative expression of the luciferase reporter activity in vivo. In mice bearing implants of cells expressing our FRB-NLuc/CLuc-FKBP fusion pair, repetitive bioluminescence imaging showed dose- and time-dependent luciferase activity induced by rapamycin with a maximal in vivo signal-to-background ratio of greater than 20 :1. 4 Conclusions These studies demonstrate that noninvasive molecular imaging of protein-protein interactions may enable investigators to determine how intrinsic binding specificities of proteins are regulated in a wide variety of normal and pathophysiologic conditions.

Last, but not least, a main concern of radiolabeled peptides is their metabolic instability, concerning not only the peptide part, but also the stability of the metal-chelator complex or the radiohalogen bond. , a high rate of complexation, the practicability of radiolabeling, the availability of the radionuclide and some other biochemical properties of the metal and metal-chelator complex that will be discussed later in this chapter. 46 H. R. 2 Radiopeptides and Potential Targets of Radiopeptides in Diagnosis and Therapy Radiopeptides are composed of a biologically active peptide coupled to a chelator for labeling with radiometals or coupled to prosthetic groups for halogenation.

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