Modified-Release Drug Delivery Technology, Second Edition by Michael J. Rathbone, Jonathan Hadgraft, Michael S. Roberts,

By Michael J. Rathbone, Jonathan Hadgraft, Michael S. Roberts, Majella E. Lane

This quantity Second Edition describes the anatomical, physiological, pharmaceutical, and technological points of supply routes, present in parts like:

  • Oral
  • Ocular
  • Dermal and transdermal
  • Vaginal
  • Colonic
  • Oral mucosal
  • Nasal
  • Pulmonary

Providing perception and significant review of the various to be had and rising converted unlock drug supply structures for his or her present and destiny price, issues include:

  • modified drug unencumber panorama; educational, regulatory, and highbrow estate viewpoints
  • I-vation Sustained unlock Intravitreal System
  • ViaNase Intranasal machine and regulated particle dispersion expertise Platform
  • Microneedles for drug supply, PassPort procedure, Dot-Matrix know-how, ultrasound, iontophoretic and applied sciences, DiretcHaler Nasal expertise, intravaginal ring structures, Supravail, Vagisite, C-Vad™ Vaginal Insert, and ‘Smart’ Vaginal supply Systems
  • the AERx® Pulmonary Drug supply System
  • AAD-Adaptive aerosol supply technology
  • nebulizer applied sciences and dry powder inhaler systems

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Additional resources for Modified-Release Drug Delivery Technology, Second Edition

Example text

Generally, drug diffusion through the coating barrier controls the release rate. Depending on the drug solubility within the core upon water penetration and on the drug loading, two types of reservoir systems can be distinguished: n n Devices with a non-constant activity source. In this case, only dissolved drug exists within the system’s core upon water penetration (Fig. 3). Thus, drug molecules that diffuse out of the device are not replaced and the drug concentration at the inner membrane’s surface decreases with time.

Despite this less than ideal situation, which should be qualified by saying that this type of regulatory exclusivity is watertight, the technology does offer advantages that will help to drive the switching strategy, the Oros formulation of paliperidone is a true once-a-day, which is not always the case with Risperdal. The formulation also removes the need for titration at the onset of therapy; the complement long-acting injectable formulation of paliperidone palmitate has a longer period of action and can be injected less frequently, about six weeks.

In the three years before generic substitution occurred, revenues increased by approximately $48 million (Datamonitor), but the combination of clinical and launch costs probably make this a marginal product in terms of return on investment. Xanax XR was never able to gain the momentum of Concerta, and although this strategy would have worked well for life cycle extension it did not work well as a means to revitalize the market for this compound. There are a limited number of examples where reformulation has delivered a benefit to therapy to the extent that Concerta and Adderal XR have and these were more associated to the particular problems associated with the disease demographic than any unusual property of the formulation itself.

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