By Ulrich Rodeck, Meenhard Herlyn (auth.), Larry Nathanson (eds.)
Where do you start to seem for a up to date, authoritative article at the prognosis or administration of a selected malignancy? The few common oncology textbooks are regularly old-fashioned. unmarried papers in really good journals are informative yet seldom finished; those are extra frequently initial experiences on a truly restricted variety of sufferers. definite common journals usually submit reliable in-depth reports of melanoma subject matters, and released symposium lectures are usually the easiest overviews to be had. Un thankfully, those studies and vitamins seem sporadically, and the reader can by no means ascertain while an issue of specified curiosity can be coated. melanoma remedy and study is a sequence of authoritative volumes that goal to fulfill this want. it's an try and identify a severe mass of oncology literature protecting almost all oncology issues, revised often to maintain the assurance brand new, simply to be had on a unmarried library shelf or by means of a unmarried own subscription. we've approached the matter within the following type: first, by means of dividing the oncology literature into particular subdivisions corresponding to lung can cer, genitourinary melanoma, pediatric oncology, etc.; moment, via asking emi nent specialists in each one of those components to edit a quantity at the particular subject on an annual or biannual foundation. every one subject and tumor variety is roofed in a quantity showing often and predictably, discussing present prognosis, staging, markers, all kinds of therapy modalities, simple biology, and more.
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Additional info for Malignant Melanoma: Biology, Diagnosis, and Therapy
Pros Am Soc Bioi Chern 45:18221827, 1986. 39. Thurin J, Thurin M, Elder DE, Steplewski Z, Clark WH, Koprowski H: GD2 ganglioside biosynthesis is a distinct biochemical event in human melanoma tumor progression. FEBS Letters 208:17-22, 1986. 40. Livingston PO, Natoli EJ, Calves Ml, Stockert E, Oettgen HF, Old U: Vaccines containing purified GM2 ganglioside elicit GM2 antibodies in melanoma patients. Proc Nat! Acad Sci USA 84:2911-2915, 1987. 41. Kono K, Tsuchida T, Ravindranath MH, Saxton RE, lrie RF: Gangliosides as tumor markers of human melanoma.
UCLASO-M25 showed a high degree of binding to the lectin. The isolated gangliosides after base treatment converted to a slower migrating species identical with G03 (Figure 1). In one of the biopsied specimens (UCLA-HL-85), O-acetyl G03 constituted 18% of the total gangliosides and the tissue was devoid of any detectable G02 in an overloaded TLC. In the absence of O-acetyl GM3, the occurrence of O-acetyl G03 with G03 and their relative ratios in the M-25 melanoma cell line and in biopsied melanoma (UCLA-HL-85) suggest that the precursor of O-acetyl G03 could be G03.
Cancer Res 47:3057-3061, 1987. 14. Herrler G, Klenk H-D: The surface receptor is a major determinant of the cell tropism of Influenza C Virus. Virology 159:102-108, 1987. 15. Dippold WG, Dienes HP, Knuth A, Meyer zum Buschenfelde K-H: Immunohistochemical localization of ganglioside GD3 in human malignant melanoma, epithelial tumors and normal tissues. Cancer Res 45:3699-3705, 1985. 16. Graus F, Cordon-Cardo C, Houghton AN, Melamed MR, Old, LJ: Distribution of the ganglioside GD3 in the human nervous system detected by R24 mouse monoclonal antibody.