By Werner F. G. Stehr, Siegfried Breyer
Leichte und Mittlere Artillerie auf Deutschen Kriegsschiffen КНИГИ ;ВОЕННАЯ ИСТОРИЯ Издательство: Podzun-Pallas-VerlagСерия: Marine-Arsenal S18Автор(ы): Wemer F.G. Stehr, Siegfried BreyerЯзык: GermanГод издания: 1999Количество страниц: 52ISBN: 3-7909-0664-6Формат: pdf (300 dpi)Размер: 25.3 mbRapid0
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26 The Recent History of Platelets in Thrombosis and Other Disorders thought were small aggregates, it still contracted the heart–lung preparation in different ways and damaged the heart in various ways. 81 From my point of view, because of these substances I could not assay what turned out to be noradrenaline in the plasma after the sympathetic nerves had been stimulated. I then discovered by chance, not with any hypothesis-driven ideas, that dihydro-ergotamine would block the spätgift. So I used dihydroergotamine and was able to assay on the smooth muscle of blood vessels, the noradrenaline and maybe small traces of adrenalin present when you stimulated the sympathetic nerves.
And I have to say that even now Born aggregometry is the gold standard. There are other techniques that are available for measuring platelet aggregation, but Born aggregometry continues to be the gold standard. It is not perfect. 49 It’s at that point that the optical density of the sample starts to change. The technique tells you nothing about any microaggregation that may have occurred before that. Of course, using Born aggregometry, all you are getting is information on the ability of platelets to aggregate together in the absence of other blood cells, and it turns out that other blood cells are very important in determining what platelets do.
I have been told that there are thousands of optical aggregometers around the world, and am often asked why I did not patent the device. 21 So the idea just never came up. 22 We characterized aggregation with respect to velocity and temperature and pH dependence, and discovered two essential cofactors of aggregation, namely calcium and fibrinogen;23 and the suggestion that fibrinogen formed ‘bridges’ 21 See Macfarlane (1979). htm (visited 14 October 2004). 8 22 See note 11. 23 Born and Cross (1964); Cross (1964).