IVIG Therapy Today by Stanley A. Schwartz (auth.), Mark Ballow (eds.)

By Stanley A. Schwartz (auth.), Mark Ballow (eds.)

It has been little greater than a century due to the fact Emil von Behring and his colleagues (1890) confirmed that the blood of tetanus-immune rabbits contained an element that may be transferred to nonimmune animals to guard them opposed to tetanus. those observations, including the paintings of Paul Ehrlich, began scientists at the lengthy and intricate route to our current knowing of the humoral, or B-cell, immune method. those early stories resulted in Nobel prize awards for von Behring (1901 ) and Ehrlich (1908), each one of whom contributed a lot to our wisdom of the B-cell immune method. within the early twentieth century it used to be well-known that the serum of people who had lately suffered infection contained a protecting humoral issue which may be transferred to a nonimmune individual, thereafter affording that particular defense opposed to the infectious agent that had brought on sickness. In 1933 McKhann and Chu suggested placental extract containing the globulin fraction might regulate measles. despite the fact that, it was once no longer till 1939 that Tiselius and Kabat confirmed that the antibodies liable for safety opposed to those infectious issues resided in the gammaglobulin plasma fraction. In an enormous leap forward, Cohn in 1944 validated a style for the fractionation and purification of this plasma gammaglobulin fraction. those approaches, that are in response to chilly ethanol precipitation of plasma, produce a comfortably adaptable, large-scale fractionation process that remains applied to at the present time within the coaching of industrial gammaglobulin.

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C. (1987), Transfusion 27, 28-31. 22. Moscow, J. , and Fricke, W. A Transfusion 27, 248,249. 23. Warrier, I. and Lusher, J. M. (1984), Am. J. Med. 76 (Suppl. 3A), 193-198. 24. Friedman, C. A, Wender, D. , Temple, D. , and Rawson, J. E. (1989), Am. J. Perinatol. 6, 453-456. 25. Weisman, L. , and Fischer, G. W. (1990), Pediatr. Res. 27, 277A (abstract no. 1647). 26. , Zaidi, M. , Haque, S. , and EI-Swailam, M. (1986), Pediatr. Infect. Dis. 5,622-625. 27. Steihm, E. R. and Fudenberg, H. H. (1966), Pediatrics 37, 715-727.

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By contrast, Krozman et al. (25) reported that concentrations of IgG and IgA, but not IgM, were prognostic indicators. Other studies suggested that reduced immunoglobulin concentrations were an indirect measure of prognosis; low levels tended to correlate with advanced stages of disease, as defined by the Rai classification (17,23,26). These stages are associated with a comparatively short survival. Most patients with eLL have decreased capacities to mount antibody responses following immunization with test antigens (Table 3) (27).

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