Imaging and Focal Therapy of Early Prostate Cancer by Joseph A. Graversen M.D., Jaime Landman M.D. (auth.), Thomas

By Joseph A. Graversen M.D., Jaime Landman M.D. (auth.), Thomas J. Polascik (eds.)

Imaging and Focal remedy of Early Prostate Cancer evaluates the medical proof for the evolving pattern to regard low to intermediate possibility, clinically localized prostate melanoma in a focally ablative demeanour with novel gland-preserving, focal remedy equipment. quite a few ablative units comparable to excessive depth targeted ultrasound, irreversible electroporation, photodynamic treatment, cryotherapy and laser ablation, between others, are mentioned in regard to their strengths and boundaries as a healing modality. Emphasis is put on tumor level shift in the direction of early level illness with a rise in unilateral as opposed to bilateral cancers demonstrated via ultimate pathology overview of enormous prostatectomy sequence. present and new techniques to picture melanoma foci in the prostate (3-Dimensional contrast-enhanced transrectal ultrasonography, multiparametric magnetic resonance picture with spectroscopy, and so forth) are awarded in addition to biopsy thoughts to map prostate melanoma. sufferer choice, therapy technique, results and protection matters which may offer appropriate melanoma keep an eye on and greater caliber of lifestyles for sufferers are all coated intimately.

Written by way of specialists within the box and lavishly illustrated with unique line-art and pictures, Imaging and Focal treatment of Early Prostate melanoma is a innovative quantity important to practitioners focusing on the remedy and administration of prostate cancer.

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Extra info for Imaging and Focal Therapy of Early Prostate Cancer

Sample text

Potency was preserved in 7 of the 9 men, with one requiring use of a phosphodiesterase-5 (PDE5) inhibitor. 2) [92–95]. There is still significant heterogeneity; for example, most studies only required transrectal biopsy while one required transperineal mapping biopsy prior to treatment. Additionally, the definition of cancer control was not standardized. Most studies used the American Society for Therapeutic Radiology and Oncology (ASTRO) definition of three consecutive rises above the nadir PSA.

Klotz L. Active surveillance for prostate cancer: for whom? J Clin Oncol. 2005;23(32):8165–9. 37. Roemeling S, Roobol MJ, de Vries SH, et al. Active surveillance for prostate cancers detected in three subsequent rounds of a screening trial: characteristics, PSA doubling times, and outcome. Eur Urol. 2007;51(5):1244–50 (discussion 1251). 38. Cooperberg MR, Cowan JE, Hilton JF, et al. Outcomes of active surveillance for men with intermediate-risk prostate cancer. J Clin Oncol. 2011;29(2):228–34. 39.

Image-guided focal ablation of the tumor is employed, sparing normal tissue so potency and continence are maintained. New biomarkers for disease burden are used in combination with improved imaging techniques for posttreatment monitoring so that the burden of repeat biopsies is reduced. In this scenario, both active surveillance and focal therapy play major roles in helping a man avoid radical treatment. Development and validation of new tools for disease management will allow urologists to finally practice personalized medicine for their patients diagnosed with low-risk, localized prostate cancer.

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