IgE Receptor (FcεRI) Function in Mast Cells and Basophils by Majed M. Hamawy

By Majed M. Hamawy

The excessive affinity IgE receptor (FceRI) performs a primary function in allergic illnesses together with bronchial asthma, allergic rhinitis, atopic dermatitis, foodstuff and drug hypersensitivity. Manipulating the functionality of this receptor is critical for controlling the onset of allergic illnesses. Written by way of top scientists within the box, this ebook is the 1st entire monograph to hide quite a few points of FceRI constitution, sign transduction and serve as. hence, the e-book is effective for researchers/students engaged on FceRI and on different receptors. additionally, clinicians who're taken with broadening their wisdom of the FceRI function in allergic illnesses will locate this ebook useful.

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Metzger H, Alcaraz G, Hohman R et al. The receptor with high affinity for immunoglobulin E. Ann Rev lmmunol 1986; 4:419-70. 15. Blank U, Ra C, Miller L et al. Complete structure and expression in transfected cells of high affinity lgE receptor. Nature 1989; 337:187-89. 16. Kinet J-P, Metzger H, Hakimi J et al. A 27 cDNA presumptively coding for the a subunit of the receptor with high affinity for immunoglobulin E. Biochemistry 1987; 26:4605-10. 17. Koch an J, Pettine LF, Hakimi J et al. Isolation of the gene coding for the a subunit of the human high affinity lgE receptor.

23 This aspect of FcERI signaling is discussed in chapter 7. MECHANISMS OF FcERI-INDUCED TYROSINE PHOSPHORYLATION TYROSINE PHOSPHORYLATION OF FccRI SUBUNITS Tyrosine phosphorylation of FcERI-~ and y subunits is detected within 5 second stimulation with multivalent antigen and is fully reversed upon addition of excess monovalent hapten. 25 ·26 In 1987, Seagrave et al reported that addition of excess hapten to antigen-stimulated mast cells resulted in immediate cessation of activation signal but not in immediate disaggregation of aggregated receptors.

Padlan EA, Davies DR. A model of the Fc of immunoglobulin E. Mol Immunol1986; 23(10):1063-75. 59. Takatsu K, Ishizaka T, Ishizaka K. Biologic significance of disulphide bonds in human IgE molecules. J Immunol 1975; 114: 1838-45. 60. Rousseaux-Prevost R, Rousseaux J, Bazin H et al. Differential reduction of the inter- 29 chain disulphide bonds of rat immunoglobulin E: relation to biologica! activity. Mol Immunol 1984; 21:233-41. 61. Helm BA, Marsh P, Vercelli D et al. The mast cell binding site on human immunoglobulin E.

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