By Regino Perez-Polo, Steffen Roßner, Abel Lajtha
Within the animal frightened process, a really excessive metabolic turnover, fragile yet steep ionic gradients, and morphological and structural constraints - dictated by means of the need for steered neuronal transmission of electric impulses and invaluable plasticity - bring about a hugely fragile organ approach. the following, we handle a small sampling of significant ingredients of neural functionality on the mobile and molecular point that play very important roles in improvement and getting older, endogenous procedures that embrace positive factors of allostasis or the dynamic shifts in set issues for particular homeostatic mechanisms linked to improvement and getting older. those chapters rigidity the dynamic gains of neuronal responses to inner (developmental) cues or the extra destructive exterior occasions (injury and sickness) in a contemporary point of view.
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Extra resources for Handbook of Neurochemistry and Molecular Neurobiology 3rd Edition: Developmental and Aging Changes in the Nervous System
22 3 Regulation of Gene Expression by NGF—A View from the Literature . . . . . . . . . . . . . . 23 4 Long‐Term Regulation of Gene Expression by NGF—Results of a SAGE Study with PC12 Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 5 Closing Remarks . . . . . . . . . . . . . . . . . . . . . . . . .
The second is a tabular listing of identified NGF regulated transcripts that we have detected in a large‐scale SAGE comparison of the transcriptomes of naı¨ve and long‐term NGF‐treated PC12 cells. In each case, the regulated genes have been subdivided into categories based on the current information about their functional properties. Part of the appeal of putting together such a chapter is the opportunity provided by current electronic technology to easily and swiftly update and extend the information herein and to make such modifications rapidly accessible to readers.
We hope that the reader will find this information to be a useful resource that will inspire further experimental and intellectual advances regarding the development, function, and repair of the nervous system. There are two principal portions of this chapter. One is a tabular listing of the genes and gene products that have been identified in the literature as being regulated by NGF. The second is a tabular listing of identified NGF regulated transcripts that we have detected in a large‐scale SAGE comparison of the transcriptomes of naı¨ve and long‐term NGF‐treated PC12 cells.