Genetic Engineering of Animals: An Agricultural Perspective by J. Warren Evans (auth.), J. Warren Evans, Alexander

By J. Warren Evans (auth.), J. Warren Evans, Alexander Hollaender, Claire M. Wilson (eds.)

J. Warren Evans division of Animal technological know-how Texas A&M college university Station, Texas 77843 within the close to destiny, development of family animals for the construction of meals and fiber is poised to endure a revolution via the usage of contemporary breakthroughs and advances in molecular genetics, embryo manipula­ tions, and gene move structures. usage of those recommendations could have a large influence on animal agriculture by means of development of creation effi­ ciency through manipulation and keep watch over of many physiological structures. the result may be to diminish creation expenses, elevate meals construction and caliber, and decrease meals bills. health and wellbeing and health of family and different animals can be stronger because of new tools of affliction prognosis, vaccine construction, and disorder prevention practices. Genetic engineering additionally deals the potential for using animals for the advance of pharmaceutical items to learn society. study development might be en­ hanced through manipulation of the gene pool. The targets of this convention have been to debate the present prestige of animal bioengineering and to realistically examine the capability applica­ tions of present and destiny genetic applied sciences for the construction of foodstuff and fiber to satisfy the desires of our hungry global, and to supply animal sci­ entists who may need to make use of bioengineering in present or destiny re­ seek courses with present heritage information about options, ap­ plications, and methodologies.

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Flavell (1982) DNA sequences necessary for transcription of the rabbit 8-globin gene in vivo. Nature 295:120-126. , and 1. Boime (1980) Inhibition of preprotein processing in 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. ascites tumor lysates by incorporation of a leucine analog. Proc. Natl. Acad. , USA 77:1356-1360. M. Skala (1980) Nucleotide sequence analysis of the long terminal repeat (LTR) of avian retroviruses: Structural similarities with transposable elements.

Native bGH was reported by previous investigators (24,25) to nave a heterogenous NH2 terminal. Since rbGH possesses the same type of heterogeneity as authentic bGH (see "Results" above), a possibility exists that the information necessary for cleavage is an inherent part of the bGH molecule and not cell type-specific. Further experiments to test the observation are proceeding. It was of importance to determine whether bGH secreted by these mouse cells was biologically active. Concentrated culture fluids derived from L-pDA-bGH-4-13 cells were found to be biologically active in the rat tibia GH bioassay.

Lacy, T. Maniatis, S. Silverstein, and R. Axel (1979) Introduction and expression of a rabbit S-globin gene in mouse fibroblasts. Proc. Natl. Acad. , USA 76:5684-5688. A. H. Lyons, S. C. M. Rottman (1982) Cloning and nucleotide sequencing of the bovine growth hormone gene. Nucl. Acids Res. 10:7197-7210. Yaniv, M. (1982) Enhancing elements for activation of eucaryotic promoters. Nature 297:17-18. 37 MAPPING GENES IN DOMESTICATED ANIMALS Frank H. Ruddle and Rudolf Fries Department of Biology Yale University New Haven, Connecticut 06511 INTRODUCTION During the last few decades, animal breeders have been very successful in breeding animals that are superior in the production of milk, eggs, meat, and wool.

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