By Novartis Foundation, J. Craig Venter
This crucial and interesting paintings brings jointly a high-calibre workforce of specialists to debate the sensible program of genomic details to the improvement of gear. fresh technological advances have ended in a speedy acceleration in our skill to collect genetic facts. the total genetic sequences are actually identified for a number of organisms and speeded up programmes are in position for sequencing many different genomes, together with human. the rate with which entire sequencing may be comprehensive will proceed to extend as new applied sciences come on-line. In precept, the scope for constructing new diagnostic strategies and medicine is now more than at any time in human heritage, however the pathway from genetic details to usable drug is an extended and complicated one.This significant e-book covers such matters because the present cutting-edge in squencing expertise, the functions of those new applied sciences to sequencing the genomes of assorted organisms, and the problem of proteomics. extra contributions care for criminal and moral implications of the hot makes use of of genetic information, and practical genomics from the viewpoint of the pharmaceutical undefined.
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Extra resources for From Genome to Therapy: Integrating New Technologies With Drug Development
We have heard that there may be as many as half a million human proteins! Is there a consensus de¢nition of what a protein is? Is a protein a new one because it has a phosphate on it, for instance?. I was invited to this lecture at the National Zoo after we sequenced the Methanococcus genome to talk about new species, and there was a fellow talking about all the di¡erent species of squirrels that he classi¢ed by slight changes in their tail. I don't see that as much di¡erent 50 DISCUSSION than what you're doing with proteins.
Cohen: There is not just one histone deacetylase, but several members of one family. Venter: How large is each of these families? Cohen: The only one we know much about so far is the one I described, HDAC 1, but the family contains 11 members. Hochstrasser: It makes sense to worry about that. In medicine, when you give Ca2+-blocking agents, for example, they have wide-ranging e¡ects. Venter: Drugs clearly work despite our knowledge. Cohen: It is a matter of a therapeutic window. If you can give a drug at an e¡ective dose that doesn't kill the patient, that is OK.
Goodfellow: Every technique has its limitations. The limitation here is that we do not know how to de¢ne a biologically meaningful interaction in terms of a¤nity between two proteins. This isn't a criticism of your technique, but you could be missing 50% of the important interactions which occur in those complexes, because they are weak interactions. Mann: We don't claim that our technique is exhaustive. van Oostrum: It may become a little more transparent if the immunoprecipitation is followed by washes at di¡erent stringencies.