By Lawrence C. Kuo
There are a variety of first-class stories on fragment-based drug discovery (FBDD), yet there are thus far no hand-holding courses or protocols with which possible embark in this orthogonal method of supplement conventional excessive throughput screening methodologies. This Methods in Enzymology quantity deals the instruments, functional methods, and hit-to-lead examples on tips to behavior FBDD displays. The chapters during this quantity disguise equipment that experience confirmed to achieve success in producing leads from fragments, together with chapters on the way to observe computational concepts, nuclear magnetic resonance, floor plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD. additionally elaborated by means of skilled researchers in FBDD are pattern arrangements of fragments, proteins, and GPCR in addition to examples of ways to generate leads from hits.
Offers the instruments, sensible ways, and hit-to-lead examples on the best way to behavior FBDD monitors The chapters during this quantity hide equipment that experience confirmed to achieve success in producing leads from fragments, together with chapters on find out how to follow computational concepts, nuclear magnetic resonance, floor plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD
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Extra info for Fragment Based Drug Design, Volume 493: Tools, Practical Approaches, and Examples (Methods in Enzymology)
JAMES VOLUME 395. Producing the Biochemical Data (Part B) Edited by ELIZABETH A. ZIMMER AND ERIC H. ROALSON VOLUME 396. Nitric Oxide (Part E) Edited by LESTER PACKER AND ENRIQUE CADENAS VOLUME 397. Environmental Microbiology Edited by JARED R. LEADBETTER VOLUME 398. Ubiquitin and Protein Degradation (Part A) Edited by RAYMOND J. DESHAIES xlv xlvi Methods in Enzymology VOLUME 399. Ubiquitin and Protein Degradation (Part B) Edited by RAYMOND J. DESHAIES VOLUME 400. Phase II Conjugation Enzymes and Transport Systems Edited by HELMUT SIES AND LESTER PACKER VOLUME 401.
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