By U.S. Dept of Health and Human Services, NHLBI
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Extra resources for Expert Panel report 2 : guidelines for the diagnosis and management of asthma (SuDoc HE 20.3208:AS 8 9)
This study does not support the assumption that, on average, children 5–12 years of age who have mild or moderate persistent asthma have a progressive decline in lung function. Children in the placebo group did not experience a decline in postbronchodilator FEV1 over the 5-year treatment period, and they had postbronchodilator FEV1 levels similar to children in the ICS and nedocromil treatment groups at the end of the study. Observational prospective data from other studies of large groups of children suggest that the timing of the CAMP intervention was too late, as most loss of lung function in childhood asthma appears to occur in the first 3–5 years of life (Martinez et al.
Dr. Shapiro inspired in others the essence of what NAEPP hopes to offer with this updated Expert Panel Report: a clear vision for clinicians and patients to work together to achieve asthma control. References EPR. Expert panel report: guidelines for the diagnosis and management of asthma (EPR 1991). NIH Publication No. 91-3642. S. Department of Health and Human Services; National Institutes of Health; National Heart, Lung, and Blood Institute; National Asthma Education and Prevention Program, 1991.
Increased numbers of eosinophils exist in the airways of most, but not all, persons who have asthma (Chu and Martin 2001; Sampson 2000; Williams 2004). These cells contain inflammatory enzymes, generate leukotrienes, and express a wide variety of pro-inflammatory cytokines. Increases in eosinophils often correlate with greater asthma severity. In addition, numerous studies show that treating asthma with corticosteroids reduces circulating and airway eosinophils in parallel with clinical improvement.