By Stuart M. Brown(auth.)
- Six new chapters on very important subject matters of curiosity resembling multilocus SNP genotyping (SNP chips), RNAi, ChIP-chip, and genomic tiling arrays
- New variation responds to reviewers' and clients' wish for better coverage—now the main precious guide out there!
- Practical, concise precis of every little thing approximately genomics and rising applied sciences a hectic surgeon or scientific scholar may still comprehend
- Covers thoughts and methods which are in use in medication now, in addition to these at the state-of-the-art of technology correct to medication, from bioinformatics to DNA diagnostics and proteomics
- NEW: comprises chapter-end workouts, improving the application of the hot variation as a textbook
- NEW: PowerPoint slides of pictures on hand at teacher web site
Chapter 1 advent to Molecular Genetics (pages 1–30):
Chapter 2 Molecular Biology expertise (pages 31–51):
Chapter three Genome Databases (pages 53–78):
Chapter four Bioinformatics instruments (pages 79–102):
Chapter five Human Genetic version (pages 103–125):
Chapter 6 Genetic checking out for the Practitioner (pages 127–141):
Chapter 7 Gene treatment (pages 143–178):
Chapter eight Microarrays (pages 179–199):
Chapter nine research of Microarray info (pages 201–221):
Chapter 10 Pharmacogenomics and Toxicogenomics (pages 223–235):
Chapter eleven medical learn Informatics (pages 237–249):
Chapter 12 RNA Interference and MicroRNAs (pages 251–270):
Chapter thirteen substitute Splicing (pages 271–286):
Chapter 14 Genome Tiling Chips (pages 287–299):
Chapter 15 melanoma Genomics (pages 301–317):
Chapter sixteen Proteomics (pages 319–338):
Chapter 17 purchaser Genomics and family tree (pages 339–354):
Chapter 18 The Ethics of scientific Genomics (pages 355–377):
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Extra info for Essentials of Medical Genomics, Second Edition
1). The overhanging bases from the two freshly cut ends are complementary in sequence, so under the right conditions, they can pair up to form new hydrogen bonds. ” Another bacterial enzyme, known as DNA ligase, can recreate the phosphate bonds of the DNA backbone across a pair of rejoined sticky ends, effectively pasting together a new DNA molecule. 2). 1. The EcoRI restriction enzyme produces sticky ends. ) a piece of SV40 virus and a piece of Escherichia coli chromosomal DNA (Jackson et al. 1972).
The chimeric plasmid are then put back into a bacterial cell using a process called transformation—basically utilizing the bacteria’s natural ability to take up plasmid DNA from a solution. 4). Then the bacteria are harvested and large quantities of plasmid with cloned DNA can be purified. The interesting DNA fragment can be removed from the plasmid DNA by cutting again with a restriction enzyme. Some bacteria c02 JWBK238/Brown 36 September 5, 2008 22:39 Char Count= Molecular Biology Technology KANAMYCIN RESISTANCE GENE EcoRI ENDS PLASMID pSC101 TETRACYCLINE RESISTANCE GENE Fragments joined with DNA ligase RECOMBINANT PLASMID E.
These three-dimensional (3D) structures can bring distant regions of a DNA molecule into close proximity, so that proteins bound to these sites may interact with the proteins bound to the promoter region. These distant sites on the DNA that may effect transcription are known as enhancers. The total set of DNA binding proteins that interact with promoters and enhancers are known as transcription factors, and the specific DNA sequences to which they bind are called transcription factor binding sites.