By F. Cavalli (auth.), Franco Cavalli (eds.)
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Extra resources for Endocrine Therapy of Breast Cancer: Current Developments and New Methodologies
S. s. s. s. 03 ~ 1 2 3 Performance status: 0-1 2-4 Age (years): :;;50 50 - 60 ~60 Free interval (months): 0-12 12 - 60 ~60 Site of metastases: osseous only osseous + local visceral + local osseous + visceral liver (dominant) lung (dominant) 8 12 7 16 I = low dose, oral chlorambucillmethotrexate/5-fluorouracil (LMF) II = normal dose of LMP alternated continuously with FVP III = LMFP (normal dose) alternated monthly with doxorubicin (all patients received chemo/hormone therapy). Some results are, however, consistent with the outcome of the analyses of the 2 most important studies (regarding evaluation of subgroups) comparing a doxorubicin-containing regimen to CMFP (V): the SWOG study  and that of the ECOG .
Chemotherapy including vindes'ine 3 1~0 Chemotherapy vs. 4-epidoxorubicin 6 438 Chemotherapy vs. mitoxantrone 5 756 Chemotherapy vs. same chemotherapy plus vincristine 5 735 Doxorubicin vs. Cooper regimen drugs 6 855 Doxorubicin combinations vs. methotrexate combinations 7 1263 Single regimen vs. alternating non-cross-resistant regimens 8 973 Single agent vs. drug combination 10 1263 Endocrine therapy vs. endocrine therapy plus chemotherapy 12 1177 Chemotherapy vs. chemotherapy plus endocrine therapy 11 1591 Single vs.
Classification of response depends upon the sensitivity and specificity of the methods applied. A number of new methods to evaluate tumor distribution and size have been introduced over the past 10 years (ultrasound scanning, CT-scanning, MR-scanning) but for specific tumor sites, the sensitivity and specificity of the various diagnostic procedures are poorly defined. Also clinical versus histopathological criteria of assessment may add to the confusion. In a study by Cocconi et al.  the response of primary breast cancer to systemic therapy was assessed, comparing physical and mammographic examinations which, in turn, were compared with the results of histological examination following mastectomy in responding patients.