Endocrine Therapy of Breast Cancer: Concepts and Strategies by F. Cavalli (auth.), Franco Cavalli (eds.)

By F. Cavalli (auth.), Franco Cavalli (eds.)

Starting in 1986, the eu institution of Oncology has multiplied its actions in postgraduate educating, which consisted in most cases of conventional disease-orientated classes, through selling new academic tasks. this sort of is the cloister seminars, brief conferences meant for hugely certified oncologists and working with particular, debatable points of medical perform and learn. one other is the establishment of everlasting learn teams, also referred to as job forces, the place a constrained variety of top specialists are invited to satisfy annually with the purpose of defining the state-of-the-art and doubtless achieving a consensus on advancements and remedy in particular fields of oncology. This sequence of ESO Monographs was once designed with the categorical objective of disseminating the result of the main fascinating of the seminars and research teams, and offering concise and up-to-date stories of the themes mentioned. It used to be made up our minds to maintain the format extremely simple which will maintain charges to a minimal and make the monographs to be had within the shortest attainable time, therefore overcoming a standard challenge in clinical literature: that of the cloth being outmoded even sooner than ebook. Umberto Veronesi Chairman, clinical Committee ecu college of Oncology desk of Contents how one can learn this Monograph F.CAvALLI ......... . 1 Experimental innovations for learning the advance of Breast melanoma with distinct connection with Steroid Hormones, progress elements and Oncogenes R.J.B. KING . . . . . . . . . . . . . . . . . . . . . . . . .. . . . five . . .

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Nature 1986 (320) :134-139 66. Sukumar A, Notarlo V, Martin-Zanca D, Barbacid M: Induction of mammary carcinomas in rats by nitroso-methylurea involves activation of H-ras-l locus by single point mutations. Nature 1983 (306):658-661 67. H DNA into MCF-7 human breast cancer cells bypasses dependence on estrogen for tumorigenicity. science 1985 (228):725-728 68. Huang FL, CRo-chung YS: Hormone-regulated expression of cellular ras oncogne in mammary carcinomas in rats. Biochem Biophys Res Comm 1984 (123):141-147 69.

I~ply that all patients included in the same stage, rece1v1ng the same treatment, will benefit to the same extent. The real outcome of any individual case may be worse or better than expected. It is likely that parameters related to biological characteristics of the tumor itself and to its host modulate the course of the disease. Such a hypothesis may be drawn from experimental investigations using cell lines from human origin but there is, as yet, no direct application to individual tumors and their treatment.

This would suggest that ERs could be present as a result of one of the multiple changes occuring during the process of cell transformation, but it does not provide any decisive argument in favor of their activity on growth. Recent investigations have demonstrated biochemical activities which could be linked to unregulated growth: the production of a TGF a like transforming activity and of a monolayer mitogen (19), the characterization of Nerve Growth Factor receptors (20). Colonic epithelioma represents an interesting model since data on steroid receptors are available in normal and tumor tissues from human biopsies and animal experiments (21,22,23).

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