DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and by Dhiraj Bhatia, Yamuna Krishnan (auth.), Volker A. Erdmann,

By Dhiraj Bhatia, Yamuna Krishnan (auth.), Volker A. Erdmann, Jan Barciszewski (eds.)

This publication will supply most recent insights within the sensible potentials of ribonucleic acids in medine and using Spiegelmer and Spiegelzyme structures. it's going to additionally take care of a brand new form of supply platforms for mobile targeting.

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Extra resources for DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases

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3 NP–DNA Spectral Interactions Other DNA-containing nanostructures change their spectral properties upon absorption or release of DNA. Wang et al. have shown that composite LaF3:Ce3+/ Tb3+ rare earth NPs coated with positively charged poly(allylamine hydrochloride) can be quenched after electrostatic interaction with nucleic acid (Wang et al. 2011). They showed similar behavior with (styrene-co-methacrylic acid) polymer-coated carboxy-labeled NPs, though the mechanism of nucleic acid interaction here was less clear (Wang and Li 2009).

2009). CD has been especially amenable to studying DNA quadraplexes, which are important in the study of telomeres and cancer research (Paramasivan et al. 2007). While chirality is a characteristic of biomolecules, it is not ordinarily present in synthetic materials such as NPs. Nevertheless, when chiral biomolecules are attached to metallic NPs, a unique CD signal is observed, though the details of this phenomenon are still largely unknown (Gerard et al. 2011; Guerrero-Martinez et al. 2011; Li et al.

Naval Research Laboratory (RNL) Nanosciences Institute (NSI), and the Defense Threat Reduction Agency (DTRA) Joint Science and Technology Office (JSTO) Military Interdepartmental Purchase Request (MIPR) # B112582M. Characterizing Functionalized DNA for Use in Nanomedicine 37 References Afonin KA, Bindewald E, Yaghoubian AJ et al (2010) In vitro assembly of cubic RNA-based scaffolds designed in silico. Nat Nanotechnol 5:676–682 Ali ME, Hashim U, Mustafa S et al (2011) Nanoparticle sensor for label free detection of swine DNA in mixed biological samples.

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