Development of the Ocular Lens by Frank J. Lovicu, Michael L. Robinson

By Frank J. Lovicu, Michael L. Robinson

This complete learn of the developmental biology of the ocular lens will function a reference for graduate scholars and study scientists within the visible sciences and developmental biology, in addition to for ophthalmologists. rationalization of the mechanisms that govern general lens improvement is prime to our figuring out of lens problems. The lens has additionally develop into a version for learning extra advanced organ platforms. top specialists in lens improvement and constitution talk about lens induction, evolution, phone cycle law, morphology, fiber telephone differentiation, and regeneration.

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This brief and by far incomplete review of comparative lens structure and function indicates the extent of adaptive variation seen in vertebrate eyes. One thing that has remained constant amongst vertebrates is the manner in which the different parts of the eye – in particular, the lens – develop, differentiate, and continue to grow throughout life. 3. Development of the Vertebrate Lens The establishment of the unique architecture of the lens in the embryo is thought to depend on a series of inductive interactions that initiate its differentiation from head ectoderm, as discussed in Chapter 2.

However, when all the results are taken together, it becomes clear that the OV is capable of inducing a lens response in some embryonic ectoderm but not all and that the closer the ectoderm source is to the PLE, the better the lens response. The results of similar experiments with chick embryos likewise support the conclusion that there are limited circumstances in which the OV is sufficient to induce lenses in nonlens ectoderm. In the chick experiments, there was even more diversity among the sources of ectoderm tested; these sources ranged from primitive streak blastoderm to chorioallantoic Lens Induction and Determination 33 ectoderm of 8- to 9-day-old embryos.

Spemann (1901) was the first to experimentally test the role of the eye rudiment by destroying the presumptive retina of neural plate stage frog embryos without damaging the nonneural head ectoderm, and he found that these embryos subsequently lacked both a retina and a lens. While Spemann’s initial observations supported a simple 1-step model in which interaction with the forming eye rudiment induces the formation of a lens in the closely apposed ectoderm, the ensuing century of experimentation has revealed that lens determination involves more than a simple 1-step inductive interaction with the optic vesicle and begins well before the retinal rudiment contacts the presumptive lens tissue.

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