Dermatopathology: A volume in the Foundations in Diagnostic by Klaus J. Busam

By Klaus J. Busam

This new quantity within the Foundations in Diagnostic Pathology sequence packs all of state-of-the-art so much crucial dermatopathology information right into a compact, high-yield layout! Its pragmatic, well-organized method, ample full-color illustrations, and at-a-glance tables make the knowledge you would like effortless to entry. Over 1,100 full-color pictures trap the looks of a whole diversity of pores and skin lesions. And, professional seek advice performance can provide easy accessibility to the complete textual content on-line in addition to all the book's photos for stronger visible tips.

. positive aspects on-line entry to the complete textual content and the entire illustrations from the publication, with hyperlinks to PubMed, for simple referencing at expertconsult.com.

. Covers either neoplastic and non-neoplastic problems of the skin.

. presents targeted discussions of metabolic, systemic, allergic, infectious, and inflammatory epidermis ailments in addition to cutaneous neoplasms supplying you with well-rounded, entire assurance.

. bargains over 1,100 full-color, top quality photos that reveal the foremost positive aspects of a large choice of pathologic lesions providing better diagnostic assistance.

. Employs a constant, uncomplicated association all through to provide each one pathologic entity's gross and microscopic gains, prognostic and healing concerns, ancillary experiences, and differential diagnoses.

. provides info in containers and tables for at-a-glance reference.

The Foundations in Diagnostic Pathology sequence solutions the decision for clean, cheap, and easy-to-use assistance. each one region-specific quantity presents all the such a lot crucial info at the pathologic entities encountered in perform. sequence Editor: John R. Goldblum, MD, FACP, FASCP, FACG With thirteen extra contributing specialists.

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In lichen planopilaris (follicular lichen planus), the disorder is centered on the lower infundibulum and isthmus of hair follicles, where scarring alopecia may result. Annular, atrophic, vesiculo-bullous, actinic, erosive, and hyperpigmented LP are other clinical variants. Two rare overlap syndromes are the lichen lichen Planus—Clinical Facts Patient Group » Usually middle-aged adults (onset usually between ages 30 and 60 years) Site of Involvement » Oral mucosa (up to 75% of patients) » Skin of wrist, forearm, genitalia, distal lower extremity Clinical Findings » Classic skin lesions: flat-topped violaceous papules and plaques » Variants: linear, bullous, hypertrophic, atrophic, annular skin lesions » Wickham striae (network of fine white lines on surface of lesions) » Mucosa: reticular pattern (most common) of whitish linear streaks; atrophic, erosive, papular or plaque lesions » Nail: lateral thinning, longitudinal ridging, fissuring pterygium Prognosis » Clinical course variable (self-limited to chronic persistent) » Ulcerative oral, hypertrophic, and nail LP tend to persist Treatment » Corticosteroids » Retinoids » Phototherapy planus–lupus erythematosus overlap and lichen planus pemphigoides.

A, Erythematous, erosive desquamating plaques in a flexural distribution. B, Initial biopsy revealed vacuolization and pronounced pallor in the superficial epidermis. Necrolysis is not yet evident. C, Subsequent biopsy revealed only focal subcorneal pustule formation. Thus prominent necrolysis is not always a feature, and the findings may resemble psoriasis or other inflammatory disorders. (vitamin B3) deficiency (pellagra) may also exhibit necrolysis and keratinocyte pallor and are best distinguished based on clinical and laboratory features.

Variants of chronic cutaneous LE include LE profundus (lupus panniculitis), which involves the subcutaneous fat and manifests as indurated, variably ulcerated deep-seated plaques usually above the waist, and tumid lupus erythematosus, characterized by smooth infiltrated erythematous plaques. Bullous LE represents a rare manifestation of acute LE and is discussed in chapter. Histologic Features All forms of LE, with the exception of many cases of tumid LE and LE profundus, are characterized by interface dermatitis, with single necrotic keratinocytes and vacuolar alteration at the dermal-epidermal junction.

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