Combination Therapy of AIDS by Erik De Clercq (auth.), Erik D. A. De Clercq, Anne-Mieke I.

By Erik De Clercq (auth.), Erik D. A. De Clercq, Anne-Mieke I. Vandamme (eds.)

HIV an infection has been a better problem to present medication than the other viral disorder ofmodem instances. HIV results in a power an infection and the virus has an incredible genetic flexibility less than selective strain. in the course of its reproduction­ tive cycle in sufferers, HIV accumulates mutations at this sort of excessive price that the selective strain inflicted at the immune procedure, or generated by means of antiviral medicinal drugs speedily triggers the looks of get away mutants. presently on hand medicinal drugs, whilst used singly, are usually not in a position to suppressing virus replication in sufferers to the sort of point that the new release of mutations, from which a variation proof against immune assault or antiviral medications may be chosen, is avoided. this is often the most it is because mixture remedy, often of 3 medicines, has turn into the normal technique for the therapy ofAIDS. it's noticeable that virus eradication won't effectively be achieveable, in order that medicines must be taken for a protracted time or maybe lifelong for you to hold the viral load as little as attainable. no matter if the at the moment used drug mixtures may be capable of keep watch over virus replication in a selected sufferer for any such seasoned­ longed time period depends upon many elements, so much of that are addressed within the assorted chapters of this publication. the purpose of antiviral drug mixture treatment for AIDS is eventually to revive complete functionality of the immune system.

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Abstracts, p 54, no 4 Sankatsing S, Weverling G, van 't Klooste G, Prins J, Lange J (2002) TMCI25 monotherapy for I week results in a similar initial rate of decline of HIV-I RNA as therapy with a 5-drug regimen. 9th Conference on Retroviruses and Opportunistic Infections, Seattle, Washington, USA, 24-28 February 2002. Abstracts, p 54, no 5 Ruiz N, Nusrat R, Lauenroth-Mai E, Berger D, Walworth C, Bacheler LT, Ploughman L, Tsang P, Labriola D, Echols R et al. (2002) Levy R, and the DPC 083-203 Study Team.

ACTG 019 a large placebo-controlled trial compared zidovudine 500 mg qd or 1500 mg qd to placebo in the earlier stages of HIV infection: patients with less than 500 CD4 cellS/ilL after a median follow up of 51 to 61 weeks (w) had clinical and laboratory benefits when receiving zidovudine with a two- to three-fold decrease in the progression rate over placebo. Toxicity was reduced in the 500-mg arm [5]. 3 years. Indeed, in the Concorde trial comparison between immediate versus deferred therapy with zidovudine 250 mg q6h showed no difference in both arms in the 3-year estimated survival rate (92-94%) and probability of progression to AIDS defining illness (29-32%) [6].

1994) Combination therapy with zidovudine and didanosine selects for drug-resistant human immunodeficiency virus type I strains with unique patterns of pol gene mutations. 1 Infect Dis 169: 722-729 II Moyle G (2000) Toxicity of antiretroviral nucleoside and nucleotide analogues: is mitochondrial toxicity the only mechanism? Drug Saf23: 467-481 12 Collier AC, Coombs RW, Fischl MA, Skolnik PR, Northfelt D, Boutin P, Hooper CJ, Kaplan LD, Volberding PA, Davis LG et al. (1993) Combination therapy with zidovudine and didanosine compared with zidovudine alone in HIV-l infection.

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