Colposcopy in Diagnosis and Treatment of Preneoplastic by H. E. Stegner (auth.), Professor Dr. med. Hans-E. Stegner,

By H. E. Stegner (auth.), Professor Dr. med. Hans-E. Stegner, Professor Dr. med. Malcolm Coppleson (eds.)

This publication offers contemporary advancements within the epidemiology and typical historical past of the early levels of melanoma of the uterine cervix, vulva and vagina, and on major advances in therapy methods. Electrodiathermy, cryosurgery, and extra lately carbon dioxide laser have confirmed to be applicable instruments to smash the peculiar epithelia with out mutilating the organs affected. crucial unmarried issue taken with luck of those ideas is a meticulous pre-treatment evaluate of the sufferer in line with skilful colposcopic exam to figure out the whole quantity of any lesion. this may basically be performed by way of a doctor completely skilled in colposcopic analysis and with entire realizing of the histogenesis of intraepithelial neoplasia. within the current e-book the necessities for prognosis and remedy are laid down via specialists from worldwide. The contributions might be of serious worth to those that care for early detection and administration of gynecological melanoma.

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However, biopsy of the peripheral areas will frequently show that the area is not the site of intraepithelial neoplasia but a mature type of squamous epithelium which has been referred to as the congenital transformation zone (CTZ). This has great relevance to treatment, because if only the central area around the external os is the seat of CIN, then it is unnecessary to plan very radical treatment to include epithelium which is normal. It is difficult to decide which is CIN and which is CTZ, but usually CTZ is not as markedly acetowhite as CIN, nor does it show such a pronounced vessel pattern.

32 M. Coppieson Indeed, one of the two more important features of SPI is its proclivity for association with carcinogenesis, an association which the newer techniques of nucleic-acid hybridization and immune histochemistry have rapidly vindicated. Since the specific cytological and histological changes associated with the presence of wart virus are recognizable with the colposcope, powerful means for the exposure of the disease have been placed in the hands of the clinician. The widespread increase in the incidence of the virus, more especially in younger women, is regarded by some authors as being of epidemic proportions.

However, when atrophic portio findings are obtained during the period offertility, a hormonal insufficiency is highly probable. During pregnancy, increased production of hormones is also detectable - as with patients taking oral contraceptives - in the ectropionized cervical mucosa. For the colposcopist, specific hormonal and vascular conditions during pregnancy are of importance for different reasons. At the portio one frequently comes across findings which have to be rated as abnormal according to the new nomenclature.

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