Circadian Clocks: Role in Health and Disease by Michelle L. Gumz

By Michelle L. Gumz

This booklet sheds new mild at the molecular mechanisms that generate circadian rhythms. It examines how organic rhythms impression physiological procedures comparable to sleep, hormone synthesis and secretion, immunity, kidney functionality, the cardiovascular method, blood strain, and the digestive procedure. medical implications are thought of whereas exploring the effect of rhythms on neuropsychiatric problems and chronotherapy’s capability for lowering cardiovascular probability. delivering a cross-section of craftsmanship in either uncomplicated and translational (bench-to-bedside) examine, this e-book serves as a consultant for physicians and scientists who desire to examine extra concerning the impression of circadian rhythms on physiological techniques in overall healthiness and illness.

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J Neurosci 33:7145–7153. 1523/JNEUROSCI. 2013 Annayev Y, Adar S, Chiou Y-Y et al (2014) Gene Model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. J Biol Chem 289:5013–5024. 534651 Antoch MP, Song EJ, Chang AM et al (1997) Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. Cell 89:655–667 Antunes LC, Levandovski R, Dantas G et al (2010) Obesity and shift work: chronobiological aspects. Nutr Res Rev 23:155–168. 1017/S0954422410000016 Arble DM, Bass J, Laposky AD et al (2009) Circadian timing of food intake contributes to weight gain.

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2007; Bugge et al. 2012; Cho et al. 2012). Thus, the rhythmic expression of REV-ERB-α plays a key role in linking circadian rhythms with metabolism and occurs through rhythmic epigenetic regulation mediated by changes in histone proteins (Ripperger and Merrow 2011; Masri and Sassone-Corsi 2013). Other metabolic influences on circadian clock function interface with histone modifications (for reviews, see Jordan and Lamia 2013; Masri and Sassone-Corsi 2013). The rate-limiting enzyme in mammalian NAD+ biosynthesis is nicotinamide phosphoribosyltransferase (NAMPT).

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