Chemical Toxicity Prediction: Category Formation and by Mark Cronin, Judith Madden, Steven Enoch, David Roberts,

By Mark Cronin, Judith Madden, Steven Enoch, David Roberts, Diana Anderson

The target of this e-book is to supply the medical history to utilizing the formation of chemical different types, or teams, of molecules to permit for read-across i.e. the prediction of toxicity from chemical constitution. It covers the clinical foundation for this method of toxicity prediction together with the ways to staff compounds (structural analogues and / or similarity, mechanism of motion) and the instruments to accomplish this. The techniques to accomplish read-across inside a chemical type also are defined. The publication will offer concise sensible assistance for these wishing to use those equipment (in chance / danger overview) and should be illustrated with case experiences. Chemical Toxicity Prediction is the 1st ebook that addresses the concept that of classification formation and read-across for toxicity prediction in particular. This subject has particularly taken off long ago few years as a result of matters over facing the achieve laws and likewise as a result availability of the OECD (Q)SAR Toolbox. a lot (lengthy and intricate) tips is out there on classification formation e.g. from the OECD and, to a lesser quantity, the eu chemical substances organization yet there isn't any one unmarried resource of knowledge that covers all concepts in a concise effortless layout. there's a actual desire for this knowledge as in silico toxicology has come to the fore lately, essentially as a result of ecu achieve laws, but additionally because of many different drivers e.g. relief of animal checking out, Cosmetics legislation. classification formation is visible because the in basic terms functional method of make rational and obvious predictions for advanced (human) toxicological endpoints. The publication covers all of the components required to create a powerful type and practice read-across.

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Additional resources for Chemical Toxicity Prediction: Category Formation and Read-Across

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Cronin, The use of mechanisms and modes of toxic action in Integrated Testing Strategies: The report and recommendations View Online 26 . 1039/9781849734400-00001 70. 71. 72. 73. 74. 75. 76. 77. 78. Chapter 1 of a Workshop held as part of the European Union OSIRIS Integrated Project, Altern. Lab. Anim. ATLA, 2009, 37, 557. M. Hewitt, C. M. Ellison, S. J. Enoch, J. C. Madden and M. T. D. Cronin, Integrating (Q)SAR models, expert systems and read-across approaches for the prediction of developmental toxicity, Reprod.

M. Solomon, M. Stephens, J. Yager and L. Zeise, Toxicity testing in the 21st Century: A vision and strategy, J. Toxicol. Environ. Health - Part B – Crit. , 2010, 13, 51. 3. S. J. Enoch and M. T. D. Cronin, A review of the electrophilic reaction chemistry involved in covalent DNA binding, Crit. Rev. , 2010, 40, 728. View Online . 1039/9781849734400-00001 An Introduction to Chemical Grouping, Categories and Read-Across 21 4. C. M. Ellison, M. T. D. Cronin, J. C. Madden and T. W. Schultz, Definition of the structural domain of the baseline non-polar narcosis model for Tetrahymena pyriformis, SAR QSAR Environ.

Schultz, Definition of the structural domain of the baseline non-polar narcosis model for Tetrahymena pyriformis, SAR QSAR Environ. , 2008, 19, 751. 5. Organisation for Economic Co-operation and Development (OECD), Environment Health and Safety Publications, Series on Testing and Assessment No. 80: Guidance on Grouping of Chemicals, OECD, Paris, 2007. 6. 6: QSARs and Grouping of Chemicals, ECHA, Helsinki, 2008. 7. M. T. D. Cronin and D. J. Livingstone, Predicting Chemical Toxicity and Fate, CRC Press, Boca Raton, USA, 2004.

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