Cellular Therapy for Neurological Injury by Jr., Charles S. Cox

By Jr., Charles S. Cox

Cellular remedy for Neurological Injury discusses the present prestige of mobile remedy for neurological issues. the first parts of concentration contain irritating mind harm, stroke (ischemic and hemorrhagic), and spinal wire damage. The booklet explores telephone remedy techniques to those and different stipulations, whereas discussing present advances and a literature evaluate within the context of a box that's relocating quickly.

The ebook offers a translational concentration, addressing obstacles and possibilities to relocating ahead. The mechanisms of damage are explored, in addition to how those mechanisms impact the kind of phone treatment used, the course of supply, and dosing routine. Written via leaders within the box, this is often a useful source for clinicians and researchers alike.

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14:2381–2392. , 2004. Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury. Cell Mol Life Sci. 61:657–668. M. 2011. Decoding hippocampal signaling deficits after traumatic brain injury. Transl Stroke Res. 2 (4):546–555. , 2012. Postinjury treatment with rolipram increases hemorrhage after traumatic brain injury. J Neurosci Res. 90 (9):1861–1871. , 2007. Modulation of the cAMP signaling pathway after traumatic brain injury. Exp Neurol. 208 (1):145–158.

2013). gov Identifier: NCT01212679). 6 Neuronal Architecture Cyclosporin A was shown in the 1990s to protect axons following TBI in rats by inhibiting calcium-induced mitochondrial damage (Buki et al. 1999; Okonkwo et al. 1999). Preinjury inhibition of calpain, a calcium influx–mediated cysteine protease, preserves axonal integrity following TBI in rats (Buki et al. 2003). Inhibitory myelin molecules such as Nogo-A have been implicated in axonal sprouting following injury, but monoclonal antibodies against this protein did not appear to act through sprouting or cell loss protection, but still improved cognition in animal models (Lenzlinger et al.

Et al. 2014. Intra-arterial immunoselected CD34+ stem cells for acute ischemic stroke. Stem Cells Transl Med. 3:1322–1330. , 2005. Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol. 57:874–882. , 2011. Progesterone treatment normalizes the levels of cell proliferation and cell death in the dentate gyrus of the hippocampus after traumatic brain injury. Exp Neurol. 231 (1):72–81. , 2000. Neuroprotective effects of citicoline on brain edema and blood-brain barrier breakdown after traumatic brain injury.

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