Ciba Foundation Symposium 144 - Cellular Basis of by CIBA Foundation Symposium

By CIBA Foundation Symposium

Members to this symposium concentrate on the interface among genes and cells, masking genetic research, cloning reports, and the research of mobile lineages and mobile interactions. They observe how the physique axes are already made up our minds within the eggs of invertebrates and amphibia, then examine the mechanisms because the egg cleaves, in annelids, arthropods, amphibia, and mice that underlie assignation of cells to express lineages, which provide upward push to diversified tissues within the grownup. remaining chapters symbolize the molecules that mediate each one cell's specific destiny, its place within the ultimate physique plan because the results of phone sorting or, now and again, mobilephone migration.


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Extra resources for Ciba Foundation Symposium 144 - Cellular Basis of Morphogenesis

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Adv Morphol 10: 1-39 Nusslein-Volhard C, Fronhofer HG, Lehmann R 1987 Determination of anteror-posterior polarity in Drosophila. Science (Wash DC) 238: 1675-1681 Rebagliati MR, Weeks DL, Harvey RP, Melton DA 1985 Identification and cloning of localized maternal RNAs from Xenopus eggs. Cell 42:769-777 Ruiz i Altaba A, Melton D 1989a Bimodal and polar expression of the Xenopus homeobox gene Xhox 3. Development 106:173-183 Ruiz i Altaba A, Melton D 1989b Involvement of the Xenopus homeobox gene Xhox3 in embryonic pattern formation along the anterior-posterior axis.

Melton: They do have notochord and their anterior deficiencies are not caused by any delay or change in the migration of the mesoderm. In UV-irradiated embryos the mesoderm involutes late and uniformly, in these embryos that does not happen. Careful histological examination shows that embryos injected with Xhox3 have anterior mesoderm as defined by its position in the embryo. However, this ‘anterior mesoderm’ is evidently not capable of inducing anterior structures. Cooke: That information about timing is very interesting because it suggests that the spread of positional information in the mesoderm is not abnormal in these embryos.

Gene product unequally distributed in egg or locally activated. Distribution determines spatial pattern of expression of zygotic target gene. dOnly those genes that are thought to be positively regulated by the maternal gene products. approximation, there is little interaction between the components of the three systems and that large regions of the embryo are determined independently of each other (Nusslein-Volhard et a1 1987). Localization, distribution and function of the maternal signals In addition to the genetic analysis, two experimental approaches have greatly aided our understanding of the mode of action of the three systems: cytoplasmic transplantation and molecular biology.

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