Cardiac Drug Development Guide by Michael K. Pugsley (auth.), Michael K. Pugsley (eds.)

By Michael K. Pugsley (auth.), Michael K. Pugsley (eds.)

The revolution in molecular drugs makes it crucial to combine the classical and molecular techniques to drug improvement for the remedy of middle sickness, the number 1 killer in North the US and Europe. within the Cardiac Drug improvement advisor, simple clinical researchers, clinicians, and pharmacologists sign up for forces to comprehensively survey the newest breakthroughs in molecular cardiology and overview the newest drug discoveries in cardiac and cardiovascular medication. issues diversity from novel molecular goals for cardiac drug improvement, to useful endpoints for comparing cardiac drug task, to medical facets of cardiovascular therapeutics. The authors describe the main complicated tactics in cardiovascular pharmacology, together with in vivo and in vitro complete animal stories, the electrophysiological tools used to review pacemaker cells, and the applying of biochemical ideas and applied sciences to novel healing brokers. additionally mentioned are the equipment used to precise the ion channels serious about cardiovascular pharmacology, adenoviral vector supply for cardiovascular gene treatment, pharmacometrics in cardiovascular drug improvement, gender alterations in center failure, and angiogenesis cures for heart illness. every one bankruptcy concisely illustrates the innovations defined and comprises finished historical past details, designated figures and tables, and an updated checklist of crucial references.
accomplished and easy-to-understand, the Cardiac Drug improvement advisor deals pharmacologists, cardiologists, and physiologists not just a gold-standard survey of the numerous various equipment getting used to enhance new center medicines, but additionally information robust new ways that heart problems is focused, from the complete organ to the genetic level.

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6. DiFrancesco, D. and Ojeda, C. (1980) Properties of the current if in the sino-atrial node of the rabbit compared with those of the current iK, in Purkinje fibres. J. Physiol. 308, 353–367. 7. Irisawa, H. and Noma, A. (1984) Pacemaker currents in mammalian nodal cells. J. Mol. Cell Cardiol. 16, 777–781. 8. Maylie, J. and Morad, M. (1984) Ionic currents responsible for the generation of pacemaker current in the rabbit sino-atrial node. J. Physiol. 355, 215–235. 9. Bader, C. , Macleish, P. , and Schwartz, E.

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