Carcinoembryonic Antigens by Pavel Koldovsky M. D. (auth.)

By Pavel Koldovsky M. D. (auth.)

Interest within the common box of tumor immunology has grown phenomenally lately. The variety of courses con­ tinues to develop in doubtless exponential style and the top isn't but in sight. less than those stipulations, it's very tough for anybody investigator to understand the full, or perhaps the small element in which his personal efforts needs to unavoidably be restricted. Weare hence very lucky while an investigator with lengthy and extensive event within the box of tumor immunology takes the time to proportion his views of a part of that box. Dr. Koldovsky has been one of many pioneers in tumor immunology and he con­ tinues to give a contribution, in particular within the quarter of CEA. within the current survey he has reviewed the prestige of CEA, environment forth not just the literature, yet his personal interpretation of that literature. For this pastime, all staff in tumor immunology should be virtually grateful.

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For artificially induced tolerance, in fact, the opposite is more often the case. For example, a newborn rat injected with a certain antigen (human cells) exhibited tolerance when tested 2 months later but not when tested 3 months later. Although there is still no satisfactory answer to whether the continued presence of antigen is necessary to maintain tolerance, it is more likely that the presence is necessary. In some experimental systems it was found that the level of soluble protein (albumin) necessary to maintain tolerance should be 10 ng/ml.

T. t. n. t. = not tested. a Cell lines derived from adenocarcinoma colon. b Cell lines derived from intestine of a 3-month-old embryo. c Titer of cytotoxic antibodies. d Skin-derived cells from patient with tumor BTl 3. indicate how extensive is the degree of cross-reactivity between human malignant and normal human embryonic intestinal cells. There was no evidence for crossreactivity against cells derived from lung or skin cells from the same embryos. The experiments described above, do not confirm or exclude that additional specificity exists in human tumors or that human embryonic organs (tissues) have real embryonic stage-(tissue)-specific antigens not shared with tumors.

G. HSI against HSI) was most effective. However, soon after removal from patients, all rapidly growing sarcomas showed equally high immunogenic activity. The antigen is very labile; it is destroyed by freezing and thawing and by prolonged storage. BUTTLE et al. (1964) compared tumors of various histological types and found differences among these tumors. Their results, along with similar results obtained with various normal embryonic and adult tissues are summarized in Table 1. When sera from pregnant women were mixed with rat-adapted human tumor cells and injected into rats just treated with cortisone, 2 out of 50 sera inhibited tumor growth.

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