The Liver: Biology and Pathobiology, Fifth Edition by -Author-

By -Author-

Content material:
Chapter 1 Organizational rules of the Liver (pages 1–15): Joe W. Grisham
Chapter 2 Embryonic improvement of the Liver (pages 17–25): Roque Bort and Kenneth S. Zaret
Chapter three Microtubules, Actin Filaments and Motor?Mediated Vesicular shipping (pages 27–43): Ronald R. Marchelletta and Sarah F. Hamm?Alvarez
Chapter four Molecular cars (pages 45–55): Peter Satir
Chapter five Ion Pumps and Molecular automobiles: P?, F?, and V?type ATPases (pages 57–71): Sarah Bond, Daniel J. Cipriano and Michael Forgac
Chapter 6 Hepatocyte floor Polarity: Its Dynamic upkeep and institution (pages 73–105): Lelita T. Braiterman and Ann L. Hubbard
Chapter 7 Endocytosis as an important procedure in Liver functionality and Pathology (pages 107–123): Barbara Schroeder and Mark McNiven
Chapter eight Membrane shipping in Hepatocellular Secretion (pages 125–135): Susan Chi and Mark McNiven
Chapter nine Mitochondria (pages 137–146): Kasturi Mitra
Chapter 10 Nuclear Pore advanced (pages 147–155): Joseph S. Glavy
Chapter eleven Protein Maturation and Processing on the Endoplasmic Reticulum (pages 157–171): Ramanujan S. Hegde
Chapter 12 Protein Degradation and the Lysosomal approach (pages 173–189): Susmita Kaushik and Ana Maria Cuervo
Chapter thirteen Peroxisome meeting, Degradation, and disorder (pages 191–200): Peter okay. Kim
Chapter 14 hole and Tight Junctions in Liver: Composition, law, and serve as (pages 201–220): Takashi Kojima, Norimasa Sawada, Hiroshi Yamaguchi, Alfredo G. castle and David C. Spray
Chapter 15 Copper Metabolism and the Liver (pages 221–233): Michael L. Schilsky and Dennis J. Thiele
Chapter sixteen The valuable function of the Liver in Iron garage and legislation of Systemic Iron Homeostasis (pages 235–250): Tracey A. Rouault, Victor Gordeuk and Gregory Anderson
Chapter 17 issues of Bilirubin Metabolism (pages 251–256): Namita Roy Chowdhury and Jayanta Roy Chowdhury
Chapter 18 Hepatic Fatty Acid Metabolism and disorder (pages 257–270): David L. Silver
Chapter 19 Lipoprotein Metabolism and ldl cholesterol stability (pages 271–285): David E. Cohen
Chapter 20 Bile Acids and the Enterohepatic move (pages 287–304): Alan F. Hofmann
Chapter 21 Hepatocyte Basolateral Membrane natural Anion Transporters (pages 305–321): Jo H. Choi, John W. Murray and Allan W. Wolkoff
Chapter 22 Nuclear Receptors keep an eye on Bile Acid Synthesis (pages 323–337): Guorong Xu and Gerald Salen
Chapter 23 The functionality of the Canalicular Membrane in Bile Formation and Secretion (pages 339–348): Ronald P. J. Oude Elferink and Coen C. Paulusma
Chapter 24 Apical Recycling of Canalicular ABC Transporters (pages 349–358): Yoshiyuki Wakabayashi and Irwin M. Arias
Chapter 25 Cholangiocyte services in health and wellbeing and disorder: The Ciliary Connection (pages 359–369): Anatoliy I. Masyuk, Tatyana V. Masyuk and Nicholas F. Larusso
Chapter 26 The Hepatic Sinusoidal Endothelial telephone: Morphology, functionality, and Pathobiology (pages 371–388): Laurie D. Deleve
Chapter 27 Fenestrations within the Liver Sinusoidal Endothelial mobilephone (pages 389–406): Victoria C. Cogger and David G. Le Couteur
Chapter 28 Hepatic Stellate Cells (pages 407–432): Marcos Rojkind and Karina Reyes?gordillo
Chapter 29 Hepatic Fibrosis (pages 433–452): Ram?on Bataller and David A. Brenner
Chapter 30 Matrix (pages 453–467): Giuliano Ramadori and Jozsef Dudas
Chapter 31 Insulin Resistance (pages 469–483): Varman T. Samuel, Kitt F. Petersen and Gerald I. Shulman
Chapter 32 Ca2+ Signaling within the Liver (pages 485–510): Fatima M. Leite, Mateus T. Guerra and Michael H. Nathanson
Chapter 33 function of Intracellular Iron stream and Oxidant pressure in Hepatocellular harm (pages 511–520): John J. Lemasters, Akira Uchiyama, Jae?Sung Kim, Kazuyoshi Kon and Hartmut Jaeschke
Chapter 34 Regulatory Pathways of Liver Gene Expression: The principal position of Cyclic AMP (pages 521–534): Giuseppe Servillo, Maria Agnese Della Fazia and Paolo Sassone?Corsi
Chapter 35 AMPK: crucial Regulator of Glucose and Lipid Metabolism (pages 535–548): Maria M. Mihaylova and Reuben J. Shaw
Chapter 36 Liver Regeneration (pages 549–565): Nelson Fausto and Jean S. Campbell
Chapter 37 Ribosome Biogenesis and its function in phone development and Proliferation within the Liver (pages 567–575): Stefano Fumagalli and George Thomas
Chapter 38 Liver Repopulation via cellphone Transplantation and the position of Stem Cells (pages 577–595): David A. Shafritz, Michael Oertel, Mariana D. Dabeva and Markus Grompe
Chapter 39 Hepatic Encephalopathy (pages 597–617): Roger F. Butterworth and Javier Vaquero
Chapter forty The Kidney in Liver disorder (pages 619–638): Moshe Levi
Chapter forty-one serious function of the Liver in Coagulation (pages 639–658): Robert Fathke, Ze Peng, Basil Golding and Chava Kimchi?Sarfaty
Chapter forty two Inheritable Cholestatic problems (pages 659–679): Paul Gissen and A. S. Knisely
Chapter forty three Adaptive rules of Hepatocyte Transporters in Cholestasis (pages 681–702): James L. Boyer
Chapter forty four Pathogenesis of Portal high blood pressure (pages 703–717): Roberto J. Groszmann and Juan G. Abraldes
Chapter forty five Non?Alcoholic Fatty Liver disorder: A Pathophysiological standpoint (pages 719–741): Michael Fuchs and Arun J. Sanyal
Chapter forty six Pathophysiology of Alcoholic Liver ailment (pages 743–772): Natalia Nieto and Marcos Rojkind
Chapter forty seven irritation and Drug?Induced Liver damage (pages 773–781): Robert A. Roth and Patricia E. Ganey
Chapter forty eight Hepatocyte Apoptosis (pages 783–802): Cynthia R. L. Webster
Chapter forty nine again to the long run: A Backward look on the ahead development of Hepatitis Virus study (pages 803–806): Harvey J. Alter
Chapter 50 Molecular Biology of Hepatitis Viruses (pages 807–834): Christoph Seeger, Michael M. C. Lai and William S. Mason
Chapter fifty one Immune Mechanisms of Viral Clearance and ailment Pathogenesis in the course of Viral Hepatitis (pages 835–857): Carlo Ferrari and Mario Mondelli
Chapter fifty two scientific Implications of the Molecular Biology of Hepatitis B Virus (pages 859–876): Timothy M. Block, Ju?Tao Guo and W. Thomas London
Chapter fifty three Viral get away Mechanisms in Hepatitis C and the scientific results of continual an infection (pages 877–897): Stanley M. Lemon, Patrizia Farci and Marc G. Ghany
Chapter fifty four present and destiny remedy for Hepatitis B and C (pages 899–919): Gary L. Davis and Jean?Michel Pawlotsky
Chapter fifty five organic ideas and medical concerns Underlying Liver Transplantation for Virus?Induced End?Stage Liver illness (pages 921–931): James R. Burton, Hugo R. Rosen and Paul Martin
Chapter fifty six Tissue Engineering of the Liver (pages 933–953): Gregory H. Underhill, Salman R. Khetani, Alice A. Chen and Sangeeta N. Bhatia
Chapter fifty seven getting older and the doubtful Roles of Sirtuins (pages 955–960): J. Fred Dice
Chapter fifty eight The Liver Proteome (pages 961–963): Laura Beretta
Chapter fifty nine Liver?Directed Gene remedy (pages 965–990): Betsy T. Kren, Clifford J. Steer, Namita Roy Chowdhury and Jayanta Roy Chowdhury
Chapter 60 interpreting the Liver melanoma Genome (pages 991–997): Ju?Seog Lee and Snorri S. Thorgeirsson
Chapter sixty one Genome?Wide Expression Profiling of Human Hepatocellular Carcinoma (pages 999–1013): Anuradha Budhu and Xin Wei Wang
Chapter sixty two mobile Cycle keep an eye on within the Liver (pages 1015–1027): Jeffrey H. Albrecht and Lisa okay. Mullany
Chapter sixty three miRNAs and Liver Biology (pages 1029–1052): Charles E. Rogler and Leslie E. Rogler
Chapter sixty four Imaging mobile Proteins and constructions: Smaller, Brighter, and quicker (pages 1053–1066): Erik Snapp
Chapter sixty five Zebrafish as a version approach for the research of Liver improvement and illness (pages 1067–1074): Randolph P. Matthews
Chapter sixty six The Hepatocyte and the melanoma mobilephone: Dr Jekyll and Mr Hyde (pages 1075–1090): Jean?Pierre Gillet, Michael M. Gottesman and Mitsunori Okabe
Chapter sixty seven The function of Endocannabinoids and Their Receptors within the keep an eye on of Hepatic capabilities (pages 1091–1103): George Kunos, Douglas Osei?Hyiaman, Sandor Batkai, buddy Pacher, Bin Gao, Won?Il Jeong, Jie Liu and Gregorz Godlewski
Chapter sixty eight Telomeres and getting older, melanoma, and Hepatic Fibrosis (pages 1105–1119): Hans L. Tillmann, Ruben R. Plentz, Yvonne Begus?Nahrmann, Andree Lechel and Lenhard ok. Rudolph
Chapter sixty nine therapy of Cirrhosis with nutrition A?Coupled Liposomes wearing siRNA opposed to warmth surprise Protein (pages 1121–1129): Yoshiro Niitsu, Yasushi Sato, Kazuyuki Murase and Junji Kato
Chapter 70 The “Green Liver” and Transcriptional law of part II cleansing Genes (pages 1131–1138): Christopher Johnson and Jonathan Arias

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Extra resources for The Liver: Biology and Pathobiology, Fifth Edition

Sample text

Large afferent and efferent vessels hemodynamically divide the parenchyma into at least eight macrovascular segments, which enable the surgical resection of large portions (segments) of the blood-filled, sponge-like liver through hemodynamic fissures between afferent and efferent blood flows (see below). PHYLOGENESIS AND EVOLUTION OF THE LIVER The multiple functions of the mammalian liver are carried out by a combination of exocrine, endocrine, and paracrine/juxtacrine mechanisms involving the several types of cell listed above, as well as stromal cells (fibroblasts), and cells forming nerves and large blood vessels.

Liver embryogenesis in mammals (see Chapter 2) begins in a few endodermal cells of the ventral foregut (the “liver bud”) located adjacent to the mesoderm of the septum transversum, which lies between the developing heart and the yolk sac and contains several types of mesenchymal cells and small blood vessels [10]. Interactions between epithelial cells of the foregut endoderm and mesenchymal cells of adjacent mesoderm direct the early development of the liver through the mediation of growth factors and cytokines [10, 11].

Blood pressure in the inferior vena cava approximates that in the terminal hepatic vein [43]. Consequently, although flow of blood through sinusoids faces little resistance, it is slow and somewhat intermittent and is assisted by negative pressure produced by respiratory expiration [43]. Possible mechanisms of regulating blood flow within sinusoids are controversial. Sinusoids appear to have limited contractile ability, possibly produced by contraction of encircling stellate cells (pericytes) [46, 47].

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