Biomedical Aspects of Histamine: Current Perspectives by Mohammed Shahid, Nancy Khardori, Rahat Ali Khan, Trivendra

By Mohammed Shahid, Nancy Khardori, Rahat Ali Khan, Trivendra Tripathi

Since its id by way of Sir Henry H. Dale a century in the past, histamine has develop into the most vital multifunctional biogenic amines within the box of biomedicine. The pharmacological results of histamine are mediated via 4 different types of membrane histamine receptors; H1R, H2R, H3R and H4R, that are all heptahelical G-protein-coupled receptors. it's been recognized to play the broadest spectrum of actions in quite a few physiological and pathological stipulations together with cellphone proliferation, differentiation, hematopoiesis, embryonic improvement, regeneration, wound therapeutic, aminergic neurotransmission and diverse mind services, secretion of pituitary hormones, legislation of gastrointestinal and circulatory services, cardiovascular process, in addition to inflammatory reactions, modulation of the immune reaction, endocrine functionality and homeostasis, and different vital parts.

This ebook is a compendium of the present nation of proven and investigational literature on Histamine, its receptors and their Agonists and antagonists. It presents a finished assessment of histamine biology within the box of biochemistry, mobilephone biology, molecular biology, immunology, hypersensitivity, neurobiology, pharmacology, microbiology and reproductive biology. the 1st part on Histamine biology and body structure leads into next sections on enzymology, pharmacology, rules of the immune approach and cellphone proliferation and position in allergic and different illnesses together with acid peptic ailments, inflammatory ailments, autoimmune and melanoma illnesses, frightened process, reproductive features and hematopoiesis. The compilation of chapters within the booklet offers the latest advances in histamine learn and bridges the elemental and scientific elements of histamine biology.

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2000). Based on these remarks, we demonstrated that activated neutrophils express HDC in the casein-induced peritonitis model and that granulocyte-macrophage colony stimulating factor (GM-CSF) has a potential 2 Regulation of Mammalian Histamine Synthesis 23 to induce HDC in immature neutrophils (Tanaka et al. 2004). Xu et al. (2006) demonstrated that mycoplasma pneumonia directly stimulated histamine synthesis in naïve neutrophils, which provoked lung and airway inflammation. We observed that activated neutrophils infiltrated into tumor tissues produced histamine, which might down-regulate local cytokine production, such as TNF-α and IFN-γ, by acting on the H2 receptor in the tumor tissues (Takahashi et al.

1 Introduction Histamine is involved in a wide variety of physiological and pathological responses, such as immediate allergy, inflammation, gastric acid secretion, neurotransmission, and immune modulation (Haas et al. 2008, Jutel et al. 2005, Leurs et al. 2005, Schubert 2007, Thurmond et al. 2008). In accord with prominent success of various histamine receptor antagonists as therapeutic drugs for immediate allergy and peptic ulcer diseases, significant progress has been made in understanding the functions of histamine H1 and H2 receptors.

1998). Many studies on the mast cell line HMC1 and the pluripotent hematopoietic cell line UT7D1 have demonstrated that HDC-gene expression is subject to post-transcriptional control. Therefore, the chromosomal configuration and methylation of the HDC-promoter is likely to account for its cell-specific expression (Maeda et al. 1998, Oh et al. 2001). It has also been reported that PMA stimulates a strong increase in HDC 1 Overview of Histamine Synthesis, Regulation and Metabolism 7 activity which is affected by actinomycin D and that is not paralleled by enhanced HDC mRNA expression.

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