Biology of Aging by R. Zwilling (auth.), Professor Dr. Robert Zwilling,

By R. Zwilling (auth.), Professor Dr. Robert Zwilling, Professor Dr. Cesare Balduini (eds.)

bhe goal of the e-book used to be to not concentration the age-dependent transformations of 1 particular organic structures or phenomena, however the test used to be pursued to hide numerous fields during which the organic learn on getting older is occurring. the basic goal of this making plans was once to provide the PhD scholars a complicated textual content that can increase the potential of an interdisciplinary dialogue on a large and complicated box that's very compatible to be applied for instance of the relationship present among complex educating and experimental research.

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This was better shown by the assay of MetSO residues than by thiol titration, when studies were carried out on ghost membranes. MetSO assay provided evidence of a significant increase in the oxidation of methionine from young to mature and senescent erythrocytes, whereas no significant difference appeared between mature and senescent cells (Fig. 2). The amount of MetSO in middle-aged erythrocytes is 500,10 higher than in membrane proteins of young cells, but it does not increase further. '~-SH 100 b~~~ ~ ~ 50 bend 4 1 bend 42 1/T-1--r--r-I/...

At the level of the membrane, slight modifications of the covalent structure of components have been described, produced by processes like oxidation [40 - 42], proteolysis [26, 43], glycation [44], methylation and transamidation [45], and modification of topology and topography of proteins have been reported or hypothesized [20, 27, 28, 46]. Most of these modifications are effective in promoting autoantibody binding and/or phagocytosis in vitro, thus supporting a possible role for each of these mechanisms in determining recognition and removal of senescent cells.

20 70. 19 69. 2. Oxidative state of membrane proteins during red cell life span was quantitated by measuring methionine sulfoxide (MetSO) [54] and thiol group content [58] of ghost membranes obtained from erythrocytes of different ages, density separated by centrifugation in autologous plasma [53 - 55] and characterized for their creatine content as a cell-age parameter [56, 57]. Oxidative state of individual membrane proteins was determined in intact cells by measuring the amount of the thiol-reagent N-(7-dimethylamino-4-methylcoumarinyl)-maleimide (DACM) bound in situ by each membrane protein [58) 32 A.

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