By Gerhard Krauss(auth.)
Now the up-to-date moment version of this bestselling name is on the market as softcover!
Intracellular sign transduction, rules of mobile actions, tumor formation, apoptosis - how do they paintings? those questions became a primary subject in Biology and organic Chemistry. the significance of this box is reflected within the 1999 Nobel prize for body structure that went to G. Blobel for his findings in protein shipping regulation.
during the last decade there was nice development within the figuring out of the molecular foundation of sign transduction, and lots of proof at the moment are easy wisdom for each medicinal chemist, biochemist, and biologist. due to the fact that an indispensable description of mobile law and sign transduction is scarcely coated in textbooks, this ebook fills a true hole. ranging from the foundations of gene legislation and rules of enzyme job, the themes of this publication disguise functionality, constitution, and indispensable development of signalling pathways plus an in depth description of some of the kinds of companies reminiscent of moment messengers, protein kinases, and transmembrane receptors. critical mobile approaches like mobilephone cycle rules, oncogenesis and apoptosis are mentioned in gentle of the homes of the signalling molecules concerned. With didactic ability and readability the writer relates the saw organic phenomena to the underlying biochemical processes.
This booklet is really books: legislation and sign Transduction.
Chapter 1 The legislation of Gene Expression (pages 1–88):
Chapter 2 The legislation of Enzyme task (pages 89–118):
Chapter three functionality and constitution of Signaling Pathways (pages 119–147):
Chapter four Signaling through Nuclear Receptors (pages 148–172):
Chapter five G?Protein Coupled sign Transmission Pathways (pages 173–215):
Chapter 6 Intracellular Messenger ingredients: “Second Messengers” (pages 216–246):
Chapter 7 Ser/Thr?Specific Protein Kinases and Protein Phosphatases (pages 247–285):
Chapter eight sign Transmission through Transmembrane Receptors with Tyrosine?specific Protein Kinase job (pages 286–323):
Chapter nine sign Transmission through Ras Proteins (pages 324–349):
Chapter 10 Intracellular sign Transduction: the Protein Cascades of the MAP Kinase Pathways (pages 350–357):
Chapter eleven Membrane Receptors with linked Tyrosine Kinase task (pages 358–376):
Chapter 12 different Receptor sessions (pages 377–384):
Chapter thirteen legislation of the phone Cycle (pages 385–419):
Chapter 14 Malfunction of Signaling Pathways and Tumorigenesis: Oncogenes and Tumor Suppressor Genes (pages 420–454):
Chapter 15 Apoptosis (pages 455–472):
Chapter sixteen Ion Channels and sign Transduction (pages 473–493):
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Extra info for Biochemistry of Signal Transduction and Regulation, Second Edition
The zinc ion does not contact the DNA directly. In Zif268 the zinc motif participates directly in the DNA-binding via formation of a H-bond between the His residue of the zinc complex and the N7 of a G:C base pair of the DNA. 2 Protein-Nucleic Acid Interactions as a Basis for specific Gene Regulation 7 Fig. 3. Complexation of Zn2+ in the Zn-binding motif. a) classical Zn2+ Cys2His2 finger; b) Zn2+ Cys4 binding motif; c) (Zn2+)2 Cys6 binding motif. Fig. 4. Structures of Zn2+ binding motifs. a) TFIIA-like Zn2+ Cys2His2 finger; b) the binuclear (Zn2+)2 Cys6 motif of the GAL4 transcription activator; c) The DNA-binding domain of the gluccocorticoid receptor.
Kinking of the DNA is observed, for example, in the DNA complex of the CAP protein, as well as for the TATA-box binding protein. In the complex of the CAP protein there are two successive kinks in the DNA, each of which lead to a bending of ca. 40°, resulting in a net bend of 80°-90° (Fig. 15). The TATA-box binding protein causes a kinking of the bound DNA at an angle of ca. 100° (Fig. 16). The flexibility of the alternating purine-pyrimidine sequences of the binding site favor a prominent deformation of the DNA with little energy requirement.
Dimer formation is a prerequisite for the exact positioning of the N-terminal basic end in the major groove of the DNA. 4). The Helix-Loop-Helix Motif One example of the basic helix-loop-helix motif (HLH-motif) is found in the eucaryotic transcription factor Max (Fig. 2). 2 Protein-Nucleic Acid Interactions as a Basis for specific Gene Regulation 11 Fig. 7. Basic leucine zipper and helix-loop-helix motif in complex with DNA. A) The basic leucine zipper of the transcription activator GCN4 of yeast consists of two slightly curved § -helices, which dimerize with the help of the leucine zipper motif.