By Douglas J. Martin BS, Edward G. Randles PhD, Marina Ramirez-Alvarado PhD (auth.), Morie A. Gertz, S. Vincent Rajkumar (eds.)
An updated reference in this interesting set of advanced issues, this publication positive factors the main finished options for diagnosing, classifying, imaging, treating, and coping with amyloidosis in a number of organ platforms. valuable to the spectrum of practitioners from citizens to sub-specialists, this booklet is a succinct authoritative textual content written by means of leaders within the box. The authors supply guide on all kinds of amyloidosis - together with fundamental amyloidosis (AL), secondary amyloidosis (AA), and familial amyloidosis. With crucial remedy algorithms, Amyloidosis: analysis and remedy is the gold-standard for all hematologists, oncologists, and internists taking good care of sufferers with this disease.
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Extra info for Amyloidosis: Diagnosis and Treatment
In patients with endomyocardial biopsy-proven cardiac amyloidosis, late gadolinium enhancement shows good sensitivity (80%) and excellent specificity (94%) , being strongly correlated with heart failure severity as assessed by brain natriuretic peptide . Magnetic resonance relaxometry, measuring T1 and T2 relaxation times of the left ventricular myocardium, might improve the diagnostic reliability of this technique , and tissue characterization of the myocardium by T1 quantification predicts survival .
Palladini et al. Scintigraphy with 99m Tc-Labeled Phosphate Derivatives Radiolabeled phosphate derivates were developed as bone tracers and they are believed to localize to amyloid deposits because of their relevant calcium content. In 1977 Kula et al. visualized calcifications in amyloid deposits with 99m Tcdiphosphonate . Since then, several phosphate derivatives have been tested in cardiac amyloidosis, including 99m Tc-pyrophosphate (99m Tc-PYP) [27–32], 99m Tc(hydroxy)methylene diphosphonate (99m Tc-MDP or 99m Tc-HMDP) , and 99m Tc3,3-diphosphono-1,2-propanodicarboxylic acid (99m Tc-DPD) [34, 35].
J Thorac Imaging 2005;20:41–6. 107. Kirchner J, Jacobi V, Kardos P, Kollath J. CT findings in extensive tracheobronchial amyloidosis. Eur Radiol. 1998;8:352–4. 108. Utz J, Swensen S, Gertz M. Pulmonary amyloidosis. The Mayo Clinic experience from 1980 to 1993. Ann Intern Med. 1996;124:407–13. 109. Pickford H, Swensen S, Utz J. Thoracic cross-sectional imaging of amyloidosis. AJR Am J Roentgenol. 1997;168:351–5. 110. Rubinow A, Celli B, Cohen A, Rigden B, Brody J. Localized amyloidosis of the lower respiratory tract.