By Roumen Pankov, Albena Momchilova (auth.), Venkatram Prasad Shastri, George Altankov, Andreas Lendlein (eds.)
This publication summarizes the NATO complicated learn Workshop (ARW) on “Nanoengineered platforms for Regenerative drugs” that used to be equipped less than the auspices of the NATO protection via technological know-how application. i need to thank NATO for aiding this workshop through a provide to the co-directors. the target of ARW used to be to discover many of the aspects of regenerative me- cine and to spotlight position of the “the nano-length scale” and “nano-scale platforms” in defining and controlling telephone and tissue environments. the advance of novel tissue regenerative techniques require the combination of latest insights rising from reports of cell-matrix interactions, mobile signalling tactics, developmental and structures biology, into biomaterials layout, through a structures strategy. The chapters within the booklet, written through the best specialists of their respective disciplines, conceal a large spectrum of themes starting from stem phone biology, developmental biology, ce- matrix interactions, and matrix biology to floor technology, fabrics processing and drug supply. we are hoping the contents of the publication will galvanize the readership into constructing regenerative drugs paradigms that mix those points into cli- cally translatable options. This NATO assembly don't have been profitable with no the well timed aid of Dr. Ulrike Shastri, Sanjeet Rangarajan and Ms. Sabine Benner, who assisted within the association and implementation of assorted components of this assembly. thank you also are due Dr. Fausto Pedrazzini and Ms. Alison Trapp at NATO HQ (Brussels, Belgium). The dedication and patience of Ms.
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Extra info for Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles: Role of Nanotechnology, and Engineering Principles
An exciting new area is self-assembling nanostructures coated with heparin which in turn can bind bFGF or VEGF; the authors showed that these structures stimulate new blood vessel formation in vivo and propose that these nanostructures could be used to promote neovascularization for TE (Rajangam et al. 2006). Technologies to create microfluidic networks seeded with endothelial cells suggest the possibility of creating pre-fabricated vascular channels (Chrobak et al. 2006; Golden and Tien 2007).
Furthermore we observed that the NH2 functionality promoted cell proliferation, but delayed cell differentiation (Gustavsson et al. 2007). This raised the possibility that stronger FN interaction could disturb the cell functionality, particularly in respect to the organization of ECM. To address this, we studied the fate of both adsorbed and secreted FN by MG-63 cells to learn more about the impact of above functionalities on matrix formation. Indeed, as shown in Fig. e. 12, left column). When reaching confluency, MG63 cells grew in a film-like structure that served as a rather three dimensional environment.
2003). 17). The amount of adsorbed FN was quantified b S3 240 S6 200 160 Smooth A3 120 A6 80 40 0 0 1 2 3 Ra (µm) 4 5 2 Amount of adsorbed fibronectin (ng /cm ) Amount of adsorbed fibronectin (ng /cm2) a 240 200 160 120 S6 S3 R = 0,98 Smooth A6 A3 80 40 0 32 34 36 38 40 42 44 46 48 Surface free energy (mJ/m2) Fig. 17 3D reconstructed images of FITC-labeled fibronectin adsorbed on the different Ti samples. “Smooth” represents plane non-blasted Ti surface. The roughness of silica (S3–9) or aluminum (A3–9) particle blasted surfaces increase step-wise from left to right (Ponsonnet et al.