Adherens Junctions: from Molecular Mechanisms to Tissue by Tony J. C. Harris (auth.), Tony Harris (eds.)

By Tony J. C. Harris (auth.), Tony Harris (eds.)

Cell–cell adhesion is key for the advance and homeostasis of animal tissues and organs. Adherens junctions (AJs) are the easiest understood cell-cell adhesion complexes. during this quantity, a gaggle of the world over well-known specialists experiences AJ biology over a variety of association; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and total animal improvement. AJs have additionally been a vital part of animal evolution, and play crucial roles in melanoma improvement, pathogen an infection and different illnesses. This e-book addresses significant questions encompassing AJ biology.
• How did AJs evolve?
• How do cadherins and catenins have interaction to gather AJs and mediate adhesion?
• How do AJs interface with different mobile equipment to couple adhesion with the total phone?
• How do AJs have an effect on telephone behaviour and multicellular improvement?
• How can irregular AJ job bring about disease?

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Example text

No significant precursor genes for metazoan classical cadherins have been discovered outside of the metazoans. 5a; Coates 2003; Dickinson et al. 2011). Studies of the cellular slime mold Dictyostelium discoideum have provided insights into the evolutionary origins of adherens junctions. This organism grows as a unicellular amoeba, and when starved, D. discoideum develops into a multicellular structure termed the fruiting body. Tip cells surrounding the stalk of the fruiting body organize into a simple epithelium (Grimson et al.

D Comparison of the basic arm grooves of p120 and β-catenin. p120 arm repeats 2–4 and β-catenin arm repeats 4–6 (PDB codes 1I7X & 3L6X) are superposed (Ishiyama et al. 2010).

2010). 2d) (Kelly et al. 2008; Miyashita and Ozawa 2007a; Miyashita and Ozawa 2007b). These observations strongly suggest that these interfaces between p120 and E-cadherin JMDcore are crucial for p120 to colocalize with E-cadherin at the cell surface and to regulate the stability of cadherin–catenin complexes by countering cadherin internalization mechanisms at AJs (Ishiyama et al. 2010). 1 The Overall Structure of β-Catenin β-Catenin is an archetypal member of the armadillo repeat protein family, and plays an integral role in establishing adherens junctions by directly interacting with 3 The Three-Dimensional Structure of the Cadherin–Catenin Complex 49 cadherin (McCrea and Gumbiner 1991; McCrea et al.

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