By Tony J. C. Harris (auth.), Tony Harris (eds.)
Cell–cell adhesion is key for the advance and homeostasis of animal tissues and organs. Adherens junctions (AJs) are the easiest understood cell-cell adhesion complexes. during this quantity, a gaggle of the world over well-known specialists experiences AJ biology over a variety of association; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and total animal improvement. AJs have additionally been a vital part of animal evolution, and play crucial roles in melanoma improvement, pathogen an infection and different illnesses. This e-book addresses significant questions encompassing AJ biology.
• How did AJs evolve?
• How do cadherins and catenins have interaction to gather AJs and mediate adhesion?
• How do AJs interface with different mobile equipment to couple adhesion with the total phone?
• How do AJs have an effect on telephone behaviour and multicellular improvement?
• How can irregular AJ job bring about disease?
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Additional info for Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease
No significant precursor genes for metazoan classical cadherins have been discovered outside of the metazoans. 5a; Coates 2003; Dickinson et al. 2011). Studies of the cellular slime mold Dictyostelium discoideum have provided insights into the evolutionary origins of adherens junctions. This organism grows as a unicellular amoeba, and when starved, D. discoideum develops into a multicellular structure termed the fruiting body. Tip cells surrounding the stalk of the fruiting body organize into a simple epithelium (Grimson et al.
D Comparison of the basic arm grooves of p120 and β-catenin. p120 arm repeats 2–4 and β-catenin arm repeats 4–6 (PDB codes 1I7X & 3L6X) are superposed (Ishiyama et al. 2010).
2010). 2d) (Kelly et al. 2008; Miyashita and Ozawa 2007a; Miyashita and Ozawa 2007b). These observations strongly suggest that these interfaces between p120 and E-cadherin JMDcore are crucial for p120 to colocalize with E-cadherin at the cell surface and to regulate the stability of cadherin–catenin complexes by countering cadherin internalization mechanisms at AJs (Ishiyama et al. 2010). 1 The Overall Structure of β-Catenin β-Catenin is an archetypal member of the armadillo repeat protein family, and plays an integral role in establishing adherens junctions by directly interacting with 3 The Three-Dimensional Structure of the Cadherin–Catenin Complex 49 cadherin (McCrea and Gumbiner 1991; McCrea et al.