Abu Ya’Qub Al-Sijistani and Kitab Sullam Al-Najat, A Study by Mohamed Abualy Alibhai

By Mohamed Abualy Alibhai

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J Biol Chem 2002;277(44):41701–5. Hisamatsu T, Suzuki M, Reinecker HC, et al. CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells. Gastroenterology 2003;124(4):993–1000. Pauleau AL, Murray PJ. Role of nod2 in the response of macrophages to toll-like receptor agonists. Mol Cell Biol 2003;23(21):7531–9. Kobayashi KS, Chamaillard M, Ogura Y, et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 2005; 307(5710):731–4. Maeda S, Hsu LC, Liu H, et al.

1%) for patients with CARD15 variants eventually developing the CD phenotype, although numbers were rather small to draw definite conclusions [149]. Despite a variety of genotype/phenotype associations within the HLA region the lack of consistency and relatively low allele frequencies of disease-associated mutations are at present a barrier to any clinical application. 24 CHAPTER 2 ...................................................................................................................................................................................................................................

11 Kuster W, Pascoe L, Purrmann J, Funk S, Majewski F. The genetics of Crohn disease: complex segregation analysis of a family study with 265 patients with Crohn disease and 5,387 relatives. Am J Med Genet 1989;32(1):105–8. 12 Orholm M, Binder V, Sorensen TI, Rasmussen LP, Kyvik KO. Concordance of inflammatory bowel disease among Danish twins. Results of a nationwide study. Scand J Gastroenterol 2000;35(10): 1075–81. 13 Thompson NP, Driscoll R, Pounder RE, Wakefield AJ. Genetics versus environment in inflammatory bowel disease: results of a British twin study.

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